Better Prognosis in Newborns with Trisomy 13 Who Received Intensive Treatments: a Retrospective Study of 16 Patients

Overview

Journal Cell Biochem Biophys

Specialties Biochemistry
Biophysics
Cell Biology

Date 2012 Apr 11

PMID 22487910

Citations 11

Authors

Keiko Tsukada

George Imataka

Hiroshi Suzumura

Osamu Arisaka

Affiliations

Soon will be listed here.

Abstract

Intensive treatment for newborns with trisomy 13 is controversial because of their lethal prognosis. We report the better life prognosis of patients with trisomy 13 who received intensive treatment. At our hospital, we provided an intensive management to such patients including resuscitation and surgical procedures as required. Herein, we present the results of a retrospective study (1989-2010) of 16 trisomy 13 cases who received an intensive treatment. None was diagnosed to have trisomy 13 before birth; 9 were delivered by C-section and oxygen was administered to all patients during postpartum resuscitation. Mechanical ventilation was used in 9 patients after tracheal intubation and tracheotomy was performed in 2 patients when withdrawing of extubation was difficult. Regarding prognosis, 9 patients died, 3 were referred to another hospital, and 4 were discharged from the hospital. Four and 7 patients died within 7 and 30 days after birth, respectively. Nine patients survived for >1 month, 7 for >180 days, and 5 for >3 years. Median survival for 16 patients was 733 days. The patients who received intensive treatments survived longer compared to the previous data. This study provides useful information concerning genetic counseling, especially from an ethical point of view, before providing intensive management to newborns with trisomy 13.

Citing Articles

Skeletal system in adult congenital heart disease.

Alonso-Gonzalez R, Massarella D, Swan L Int J Cardiol Congenit Heart Dis. 2024; 13:100460.

PMID: 39712228 PMC: 11657259. DOI: 10.1016/j.ijcchd.2023.100460.

A 29-Year-Old Patient With Patau Syndrome: A Case Report on Medical Management.

Gandhi S, Patel P, Carter T, Stutts L Cureus. 2024; 16(1):e51471.

PMID: 38298300 PMC: 10829937. DOI: 10.7759/cureus.51471.

The Co-Existence of Patent Omphalomesenteric Duct and Omphalocele in Patau's Syndrome in Saudi Arabia: A Case Report.

Beyari B, Alhassan Y, Gabra A, Awad M, Alsaggaf A Cureus. 2023; 15(12):e50793.

PMID: 38125687 PMC: 10732476. DOI: 10.7759/cureus.50793.

An infant with patau syndrome associated with congenital heart defects.

Khan U, Hussain A, Usman M, Abiddin Z Ann Med Surg (Lond). 2022; 80:104100.

PMID: 36045789 PMC: 9422041. DOI: 10.1016/j.amsu.2022.104100.

Trisomy 13 and 18-Prevalence and mortality-A multi-registry population based analysis.

Goel N, Morris J, Tucker D, de Walle H, Bakker M, Kancherla V Am J Med Genet A. 2019; 179(12):2382-2392.

PMID: 31566869 PMC: 6848757. DOI: 10.1002/ajmg.a.61365.

References

Baty B, Blackburn B, Carey J . Natural history of trisomy 18 and trisomy 13: I. Growth, physical assessment, medical histories, survival, and recurrence risk. Am J Med Genet. 1994; 49(2):175-88. DOI: 10.1002/ajmg.1320490204. View

Root S, Carey J . Survival in trisomy 18. Am J Med Genet. 1994; 49(2):170-4. DOI: 10.1002/ajmg.1320490203. View

Kosho T . Care of children with trisomy 18 in Japan. Am J Med Genet A. 2008; 146A(11):1369-71. DOI: 10.1002/ajmg.a.32355. View

Nishida H, Sakamoto S . Ethical problems in neonatal intensive care unit--medical decision making on the neonate with poor prognosis. Early Hum Dev. 1992; 29(1-3):403-6. DOI: 10.1016/0378-3782(92)90200-z. View

Goldstein H, Nielsen K . Rates and survival of individuals with trisomy 13 and 18. Data from a 10-year period in Denmark. Clin Genet. 1988; 34(6):366-72. DOI: 10.1111/j.1399-0004.1988.tb02894.x. View

PATAU K, Smith D, THERMAN E, Inhorn S, Wagner H . Multiple congenital anomaly caused by an extra autosome. Lancet. 1960; 1(7128):790-3. DOI: 10.1016/s0140-6736(60)90676-0. View

Wyllie J, Wright M, Burn J, Hunter S . Natural history of trisomy 13. Arch Dis Child. 1994; 71(4):343-5. PMC: 1030016. DOI: 10.1136/adc.71.4.343. View

Petit P, Fryns J . Normal/trisomy 13 mosaicism in a 38-year-old male. Genet Couns. 1994; 5(3):311-4. View

Lin H, Lin S, Chen Y, Hsu C, Kao H, Chen M . Clinical characteristics and survival of trisomy 13 in a medical center in Taiwan, 1985-2004. Pediatr Int. 2007; 49(3):380-6. DOI: 10.1111/j.1442-200X.2007.02377.x. View

10.

BREWER C, Holloway S, Stone D, Carothers A, Fitzpatrick D . Survival in trisomy 13 and trisomy 18 cases ascertained from population based registers. J Med Genet. 2002; 39(9):e54. PMC: 1735241. DOI: 10.1136/jmg.39.9.e54. View

11.

Kosho T, Nakamura T, Kawame H, Baba A, Tamura M, Fukushima Y . Neonatal management of trisomy 18: clinical details of 24 patients receiving intensive treatment. Am J Med Genet A. 2006; 140(9):937-44. DOI: 10.1002/ajmg.a.31175. View

12.

Bos A, Broers C, Hazebroek F, Van Hemel J, Tibboel D, Molenaar J . Avoidance of emergency surgery in newborn infants with trisomy 18. Lancet. 1992; 339(8798):913-5. DOI: 10.1016/0140-6736(92)90940-5. View

13.

Graham E, Bradley S, Shirali G, Hills C, Atz A . Effectiveness of cardiac surgery in trisomies 13 and 18 (from the Pediatric Cardiac Care Consortium). Am J Cardiol. 2004; 93(6):801-3. DOI: 10.1016/j.amjcard.2003.12.012. View

14.

Forrester M, Merz R . Trisomies 13 and 18: prenatal diagnosis and epidemiologic studies in Hawaii, 1986-1997. Genet Test. 2000; 3(4):335-40. DOI: 10.1089/gte.1999.3.335. View

15.

Kaneko Y, Kobayashi J, Yamamoto Y, Yoda H, Kanetaka Y, Nakajima Y . Intensive cardiac management in patients with trisomy 13 or trisomy 18. Am J Med Genet A. 2008; 146A(11):1372-80. DOI: 10.1002/ajmg.a.32311. View

16.

Imataka G, Nitta A, Suzumura H, Watanabe H, Yamanouchi H, Arisaka O . Survival of trisomy 18 cases in Japan. Genet Couns. 2007; 18(3):303-8. View

17.

Rasmussen S, Wong L, Yang Q, May K, Friedman J . Population-based analyses of mortality in trisomy 13 and trisomy 18. Pediatrics. 2003; 111(4 Pt 1):777-84. DOI: 10.1542/peds.111.4.777. View

18.

Norup M . Attitudes towards abortion among physicians working at obstetrical and paediatric departments in Denmark. Prenat Diagn. 1998; 18(3):273-80. View