Evaluation of the Efficacy and Safety of High Dose Short Duration Enrofloxacin Treatment Regimen for Uncomplicated Urinary Tract Infections in Dogs

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2012 Apr 11

PMID 22486931

Citations 19

Authors

J L Westropp

J E Sykes

S Irom

J B Daniels

A Smith

D Keil

T Settje

Y Wang

D J Chew

Affiliations

Soon will be listed here.

Abstract

Background: Uncomplicated urinary tract infections (UTI) in dogs usually are treated with antimicrobial drugs for 10-14 days. Shorter duration antimicrobial regimens have been evaluated in human patients.

Hypothesis: A high dose short duration (HDSD) enrofloxacin protocol administered to dogs with uncomplicated UTI will not be inferior to a 14-day treatment regimen with amoxicillin-clavulanic acid.

Animals: Client-owned adult, otherwise healthy dogs with aerobic bacterial urine culture yielding ≥ 10(3) CFU/mL of bacteria after cystocentesis.

Methods: Prospective, multicenter, controlled, randomized blinded clinical trial. Enrolled dogs were randomized to group 1 (enrofloxacin 18-20 mg/kg PO q24h for 3 days) or group 2 (amoxicillin-clavulanic acid 13.75-25 mg/kg PO q12h for 14 days). Urine cultures were obtained at days 0, 10, and 21. Microbiologic and clinical cure rates were evaluated 7 days after antimicrobial treatment was discontinued. Lower urinary tract signs and adverse events also were recorded.

Results: There were 35 dogs in group 1 and 33 in group 2. The microbiologic cure rate was 77.1 and 81.2% for groups 1 and 2, respectively. The clinical cure rate was 88.6 and 87.9% for groups 1 and 2, respectively. Cure rates between groups did not differ according to the selected margin of noninferiority.

Conclusions And Clinical Importance: HDSD enrofloxacin treatment was not inferior to a conventional amoxicillin-clavulanic acid protocol for the treatment of uncomplicated bacterial UTI in dogs. Further research is warranted to determine if this protocol will positively impact owner compliance and decrease the emergence of antimicrobial resistance.

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References

ROGERS K, Lees G, Simpson R . Effects of single-dose and three-day trimethoprim-sulfadiazine and amikacin treatment of induced Escherichia coli urinary tract infections in dogs. Am J Vet Res. 1988; 49(3):345-9. View

Karachalios G, Georgiopoulos A, Adracta D . Value of single-dose ciprofloxacin in the treatment of acute uncomplicated urinary tract infection in women. Drugs Exp Clin Res. 1991; 17(10-11):521-4. View

Claxton A, Cramer J, Pierce C . A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001; 23(8):1296-310. DOI: 10.1016/s0149-2918(01)80109-0. View

Seguin M, Vaden S, Altier C, Stone E, Levine J . Persistent urinary tract infections and reinfections in 100 dogs (1989-1999). J Vet Intern Med. 2003; 17(5):622-31. DOI: 10.1111/j.1939-1676.2003.tb02492.x. View

Burkhardt J, Hill M, Turek J, Carlton W . Ultrastructural changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol. 1992; 29(3):230-8. DOI: 10.1177/030098589202900307. View

Drazenovich N, Ling G, Foley J . Molecular investigation of Escherichia coli strains associated with apparently persistent urinary tract infection in dogs. J Vet Intern Med. 2004; 18(3):301-6. DOI: 10.1892/0891-6640(2004)18<301:mioecs>2.0.co;2. View

Zalmanovici Trestioreanu A, Green H, Paul M, Yaphe J, Leibovici L . Antimicrobial agents for treating uncomplicated urinary tract infection in women. Cochrane Database Syst Rev. 2010; (10):CD007182. DOI: 10.1002/14651858.CD007182.pub2. View

Rohrich P, Ling G, Ruby A, Jang S, Johnson D . In vitro susceptibilities of canine urinary bacteria to selected antimicrobial agents. J Am Vet Med Assoc. 1983; 183(8):863-7. View

Bartges J . Diagnosis of urinary tract infections. Vet Clin North Am Small Anim Pract. 2004; 34(4):923-33, vi. DOI: 10.1016/j.cvsm.2004.03.001. View

10.

Cohn L, Gary A, Fales W, Madsen R . Trends in fluoroquinolone resistance of bacteria isolated from canine urinary tracts. J Vet Diagn Invest. 2003; 15(4):338-43. DOI: 10.1177/104063870301500406. View

11.

Llor C, Rabanaque G, Lopez A, Cots J . The adherence of GPs to guidelines for the diagnosis and treatment of lower urinary tract infections in women is poor. Fam Pract. 2010; 28(3):294-9. DOI: 10.1093/fampra/cmq107. View

12.

McGuire N, Schulman R, Ridgway M, Bollero G . Detection of occult urinary tract infections in dogs with diabetes mellitus. J Am Anim Hosp Assoc. 2002; 38(6):541-4. DOI: 10.5326/0380541. View

13.

Arav-Boger R, Leibovici L, Danon Y . Urinary tract infections with low and high colony counts in young women. Spontaneous remission and single-dose vs multiple-day treatment. Arch Intern Med. 1994; 154(3):300-4. View

14.

Ling G, Rohrich P, Ruby A, Johnson D, Jang S . Canine urinary tract infections: a comparison of in vitro antimicrobial susceptibility test results and response to oral therapy with ampicillin or with trimethoprim-sulfa. J Am Vet Med Assoc. 1984; 185(3):277-81. View

15.

Ling G, Norris C, Franti C, Eisele P, Johnson D, Ruby A . Interrelations of organism prevalence, specimen collection method, and host age, sex, and breed among 8,354 canine urinary tract infections (1969-1995). J Vet Intern Med. 2001; 15(4):341-7. View

16.

Wagenlehner F, Naber K . Treatment of bacterial urinary tract infections: presence and future. Eur Urol. 2006; 49(2):235-44. DOI: 10.1016/j.eururo.2005.12.017. View

17.

Passmore C, Sherington J, Stegemann M . Efficacy and safety of cefovecin (Convenia) for the treatment of urinary tract infections in dogs. J Small Anim Pract. 2007; 48(3):139-44. DOI: 10.1111/j.1748-5827.2006.00231.x. View

18.

Tivapasi M, Hodges J, Byrne B, Christopher M . Diagnostic utility and cost-effectiveness of reflex bacterial culture for the detection of urinary tract infection in dogs with low urine specific gravity. Vet Clin Pathol. 2009; 38(3):337-42. DOI: 10.1111/j.1939-165X.2009.00147.x. View

19.

Freitag T, Squires R, Schmid J, Elliott J, Rycroft A . Antibiotic sensitivity profiles do not reliably distinguish relapsing or persisting infections from reinfections in cats with chronic renal failure and multiple diagnoses of Escherichia coli urinary tract infection. J Vet Intern Med. 2006; 20(2):245-9. DOI: 10.1892/0891-6640(2006)20[245:aspdnr]2.0.co;2. View

20.

Naber K . Which fluoroquinolones are suitable for the treatment of urinary tract infections?. Int J Antimicrob Agents. 2001; 17(4):331-41. DOI: 10.1016/s0924-8579(00)00362-9. View