Structure of Human Adenovirus

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2012 Apr 10

PMID 22482707

Citations 54

Authors

Glen R Nemerow

Phoebe L Stewart

Vijay S Reddy

Affiliations

Soon will be listed here.

Abstract

A detailed structural analysis of the entire human adenovirus capsid has been stymied by the complexity and size of this 150 MDa macromolecular complex. Over the past 10 years, the steady improvements in viral genome manipulation concomitant with advances in crystallographic techniques and data processing software has allowed structure determination of this virus by X-ray diffraction at 3.5 Å resolution. The virus structure revealed the location, folds, and interactions of major and minor (cement proteins) on the inner and outer capsid surface. This new structural information sheds further light on the process of adenovirus capsid assembly and virus-host cell interactions.

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