Peptidolipins B-F, Antibacterial Lipopeptides from an Ascidian-derived Nocardia Sp

Overview

Journal J Nat Prod

Date 2012 Apr 10

PMID 22482367

Citations 25

Authors

Thomas P Wyche

Yanpeng Hou

Emmanuel Vazquez-Rivera

Doug Braun

Tim S Bugni

Affiliations

Soon will be listed here.

Abstract

A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.

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