Immunization Strategies Against Henipaviruses

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2012 Apr 7

PMID 22481140

Citations 17

Authors

Christopher C Broder

Thomas W Geisbert

Kai Xu

Dimitar B Nikolov

Lin-Fa Wang

Deborah Middleton

Jackie Pallister

Katharine N Bossart

Affiliations

Soon will be listed here.

Abstract

Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

Citing Articles

Cross-protectivity of henipavirus soluble glycoprotein in an model of Nipah virus disease.

Findlay-Wilson S, Thakur N, Crossley L, Easterbrook L, Salguero F, Ruedas-Torres I Front Immunol. 2025; 16:1517244.

PMID: 40078997 PMC: 11896980. DOI: 10.3389/fimmu.2025.1517244.

Recent Advances of Nipah Virus Disease: Pathobiology to Treatment and Vaccine Advancement.

Saha S, Bhattacharya M, Lee S, Chakraborty C J Microbiol. 2024; 62(10):811-828.

PMID: 39292378 DOI: 10.1007/s12275-024-00168-3.

Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination.

Welch S, Spengler J, Genzer S, Coleman-McCray J, Harmon J, Sorvillo T Sci Adv. 2023; 9(31):eadh4057.

PMID: 37540755 PMC: 10403222. DOI: 10.1126/sciadv.adh4057.

Broad-spectrum pan-genus and pan-family virus vaccines.

Tan C, Valkenburg S, Poon L, Wang L Cell Host Microbe. 2023; 31(6):902-916.

PMID: 37321173 PMC: 10265776. DOI: 10.1016/j.chom.2023.05.017.

The Immunobiology of Nipah Virus.

Liew Y, Ibrahim P, Ong H, Chong C, Tan C, Schee J Microorganisms. 2022; 10(6).

PMID: 35744680 PMC: 9228579. DOI: 10.3390/microorganisms10061162.

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