Comparison of Muscle Force After Immediate and Delayed Reinnervation Using Nerve-muscle-endplate Band Grafting

Overview

Journal J Surg Res

Specialty General Surgery

Date 2012 Apr 7

PMID 22480827

Citations 4

Authors

Stanislaw Sobotka

Liancai Mu

Affiliations

Soon will be listed here.

Abstract

Background: Because of poor functional outcomes of currently used reinnervation methods, we developed novel treatment strategy for the restoration of paralyzed muscles-the nerve-muscle-endplate band grafting (NMEG) technique. The graft was obtained from the sternohyoid muscle (donor) and implanted into the ipsilateral paralyzed sternomastoid (SM) muscle (recipient).

Methods: Rats were subjected to immediate or delayed (1 or 3 mo) reinnervation of the experimentally paralyzed SM muscles using the NMEG technique or the conventionally used nerve end-to-end anastomosis. The SM muscle at the opposite side served as a normal control.

Results: NMEG produced better recovery of muscle force as compared with end-to-end anastomosis. A larger force produced by NMEG was most evident for small stimulation currents.

Conclusions: The NMEG technique holds great potential for successful muscle reinnervation. We hypothesize that even better muscle reinnervation and functional recovery could be achieved with further improvement of the environment that favors axon-end plate connections and accelerates axonal growth and sprouting.

Citing Articles

Spatial Distribution of Motor Endplates and its Adaptive Change in Skeletal Muscle.

Yin X, Yu T, Chen B, Xu J, Chen W, Qi Y Theranostics. 2019; 9(3):734-746.

PMID: 30809305 PMC: 6376466. DOI: 10.7150/thno.28729.

Reinnervation of denervated muscle by implantation of nerve-muscle-endplate band graft to the native motor zone of the target muscle.

Mu L, Sobotka S, Chen J, Nyirenda T Brain Behav. 2017; 7(6):e00668.

PMID: 28638701 PMC: 5474699. DOI: 10.1002/brb3.668.

Muscle reinnervation with nerve-muscle-endplate band grafting technique: correlation between force recovery and axonal regeneration.

Sobotka S, Mu L J Surg Res. 2015; 195(1):144-51.

PMID: 25661741 PMC: 4385406. DOI: 10.1016/j.jss.2015.01.008.

Force recovery and axonal regeneration of the sternomastoid muscle reinnervated with the end-to-end nerve anastomosis.

Sobotka S, Mu L J Surg Res. 2012; 182(2):e51-9.

PMID: 23207170 PMC: 3593814. DOI: 10.1016/j.jss.2012.11.003.

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