An Outbreak of Post-partum Breast Abscesses in Mumbai, India Caused by ST22-MRSA-IV: Genetic Characteristics and Epidemiological Implications

Overview

Journal Epidemiol Infect

Publisher Cambridge University Press

Specialties Infectious Diseases
Public Health

Date 2012 Apr 6

PMID 22475374

Citations 13

Authors

A Manoharan

L Zhang

A Poojary

L Bhandarkar

G Koppikar

D A Robinson

Affiliations

Soon will be listed here.

Abstract

A cluster of methicillin-resistant Staphylococcus aureus (MRSA) breast abscesses in women who had given birth at a hospital in Mumbai, India was investigated retrospectively. Nineteen of 20 cases were caused by a single clone: pvl-positive, spa type 648 (Ridom t852), ccrB:dru subtype 3:0, ST22-MRSA-IV. Despite the presence of pvl and SCCmec type IV, which are common genetic markers in community-associated MRSA, this outbreak was caused by a healthcare-associated, community-onset MRSA that was common in the hospital environment. Thus, infection control practices may have an important role in limiting the spread of this virulent clone.

Citing Articles

Puerperal mastitis caused by limited community-associated methicillin-resistant (CA-MRSA) clones.

Lin Y, Lee Y, Chen Y, Tsao S, Wang W Front Med (Lausanne). 2024; 11:1378207.

PMID: 38707192 PMC: 11066212. DOI: 10.3389/fmed.2024.1378207.

Changes in molecular characteristics and antimicrobial resistance of invasive infection strains isolated from children in Kunming, China during the COVID-19 epidemic.

Ma M, Tao L, Li X, Liang Y, Li J, Wang H Front Microbiol. 2022; 13:944078.

PMID: 36033878 PMC: 9403864. DOI: 10.3389/fmicb.2022.944078.

Diversity of clonal complex 22 methicillin-resistant isolates in Kuwait hospitals.

Boswihi S, Verghese T, Udo E Front Microbiol. 2022; 13:970924.

PMID: 35992657 PMC: 9386227. DOI: 10.3389/fmicb.2022.970924.

Epidemiology and molecular characterization of Staphylococcus aureus causing bovine mastitis in water buffaloes from the Hazara division of Khyber Pakhtunkhwa, Pakistan.

Javed S, McClure J, Ali Syed M, Obasuyi O, Ali S, Tabassum S PLoS One. 2022; 17(5):e0268152.

PMID: 35512008 PMC: 9071125. DOI: 10.1371/journal.pone.0268152.

Comparative Genomic Analysis of a Panton-Valentine Leukocidin-Positive ST22 Community-Acquired Methicillin-Resistant from Pakistan.

Ullah N, Nasir S, Ishaq Z, Anwer F, Raza T, Rahman M Antibiotics (Basel). 2022; 11(4).

PMID: 35453247 PMC: 9033113. DOI: 10.3390/antibiotics11040496.

References

Rossney A, Shore A, Morgan P, Fitzgibbon M, OConnell B, Coleman D . The emergence and importation of diverse genotypes of methicillin-resistant Staphylococcus aureus (MRSA) harboring the Panton-Valentine leukocidin gene (pvl) reveal that pvl is a poor marker for community-acquired MRSA strains in Ireland. J Clin Microbiol. 2007; 45(8):2554-63. PMC: 1951240. DOI: 10.1128/JCM.00245-07. View

Ellington M, Hope R, Livermore D, Kearns A, Henderson K, Cookson B . Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007. J Antimicrob Chemother. 2009; 65(3):446-8. DOI: 10.1093/jac/dkp448. View

Nadig S, Ramachandra Raju S, Arakere G . Epidemic meticillin-resistant Staphylococcus aureus (EMRSA-15) variants detected in healthy and diseased individuals in India. J Med Microbiol. 2010; 59(Pt 7):815-821. DOI: 10.1099/jmm.0.017632-0. View

Amir L, Forster D, McLachlan H, Lumley J . Incidence of breast abscess in lactating women: report from an Australian cohort. BJOG. 2005; 111(12):1378-81. DOI: 10.1111/j.1471-0528.2004.00272.x. View

David M, Daum R . Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010; 23(3):616-87. PMC: 2901661. DOI: 10.1128/CMR.00081-09. View

Robinson D, Enright M . Evolutionary models of the emergence of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003; 47(12):3926-34. PMC: 296208. DOI: 10.1128/AAC.47.12.3926-3934.2003. View

Kondo Y, Ito T, Ma X, Watanabe S, Kreiswirth B, Etienne J . Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother. 2006; 51(1):264-74. PMC: 1797693. DOI: 10.1128/AAC.00165-06. View

Saiman L, OKeefe M, Graham 3rd P, Wu F, Said-Salim B, Kreiswirth B . Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women. Clin Infect Dis. 2003; 37(10):1313-9. DOI: 10.1086/379022. View

Stafford I, Hernandez J, Laibl V, Sheffield J, Roberts S, Wendel Jr G . Community-acquired methicillin-resistant Staphylococcus aureus among patients with puerperal mastitis requiring hospitalization. Obstet Gynecol. 2008; 112(3):533-7. DOI: 10.1097/AOG.0b013e31818187b0. View

10.

DSouza N, Rodrigues C, Mehta A . Molecular characterization of methicillin-resistant Staphylococcus aureus with emergence of epidemic clones of sequence type (ST) 22 and ST 772 in Mumbai, India. J Clin Microbiol. 2010; 48(5):1806-11. PMC: 2863868. DOI: 10.1128/JCM.01867-09. View

11.

Lina G, Piemont Y, Bes M, Peter M, Gauduchon V, Vandenesch F . Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999; 29(5):1128-32. DOI: 10.1086/313461. View

12.

Reddy P, Qi C, Zembower T, Noskin G, Bolon M . Postpartum mastitis and community-acquired methicillin-resistant Staphylococcus aureus. Emerg Infect Dis. 2007; 13(2):298-301. PMC: 2725877. DOI: 10.3201/eid1302.060989. View

13.

Goering R, Morrison D, Al-Doori Z, Edwards G, Gemmell C . Usefulness of mec-associated direct repeat unit (dru) typing in the epidemiological analysis of highly clonal methicillin-resistant Staphylococcus aureus in Scotland. Clin Microbiol Infect. 2008; 14(10):964-9. DOI: 10.1111/j.1469-0691.2008.02073.x. View

14.

Barbosa-Cesnik C, Schwartz K, Foxman B . Lactation mastitis. JAMA. 2003; 289(13):1609-12. DOI: 10.1001/jama.289.13.1609. View

15.

Amorim M, Faria N, Oliveira D, Vasconcelos C, Cabeda J, Mendes A . Changes in the clonal nature and antibiotic resistance profiles of methicillin-resistant Staphylococcus aureus isolates associated with spread of the EMRSA-15 clone in a tertiary care Portuguese hospital. J Clin Microbiol. 2007; 45(9):2881-8. PMC: 2045296. DOI: 10.1128/JCM.00603-07. View

16.

Popovich K, Weinstein R, Hota B . Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?. Clin Infect Dis. 2008; 46(6):787-94. DOI: 10.1086/528716. View

17.

Moazzez A, Kelso R, Towfigh S, Sohn H, Berne T, Mason R . Breast abscess bacteriologic features in the era of community-acquired methicillin-resistant Staphylococcus aureus epidemics. Arch Surg. 2007; 142(9):881-4. DOI: 10.1001/archsurg.142.9.881. View

18.

Smyth D, McDougal L, Gran F, Manoharan A, Enright M, Song J . Population structure of a hybrid clonal group of methicillin-resistant Staphylococcus aureus, ST239-MRSA-III. PLoS One. 2010; 5(1):e8582. PMC: 2797301. DOI: 10.1371/journal.pone.0008582. View

19.

Tinelli M, Monaco M, Vimercati M, Ceraminiello A, Pantosti A . Methicillin-susceptible Staphylococcus aureus in skin and soft tissue infections, Northern Italy. Emerg Infect Dis. 2009; 15(2):250-7. PMC: 2657610. DOI: 10.3201/eid1502.080010. View

20.

Klevens R, Morrison M, Nadle J, Petit S, Gershman K, Ray S . Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. 2007; 298(15):1763-71. DOI: 10.1001/jama.298.15.1763. View