A Novel Anticancer Diterpenoid from Jatropha Gossypifolia

Overview

Journal Nat Prod Commun

Publisher Sage Publications

Date 2012 Apr 6

PMID 22474940

Citations 2

Authors

Abiodun Falodun

Udo Kragl

Serge-Mitherand Tengho Touem

Alexander Villinger

Thomas Fahrenwaldt

Peter Langer

Affiliations

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Abstract

Jatropha gossypifolia root bark is used in ethnomedicine for bacterial infections and cancer of the lungs. Phytochemical investigation resulted in the isolation and characterization of a potent anticancer and novel lathyrane diterpenoid compound, abiodone, with an unusual methylene group. The structure of this novel compound was established by 1D, and 2D NMR spectroscopic experiments a nd confirmed by X-ray analysis.

Citing Articles

Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida.

Falodun A, Imieje V, Erharuyi O, Joy A, Langer P, Jacob M Asian Pac J Trop Biomed. 2014; 4(5):374-8.

PMID: 25182722 PMC: 3985052. DOI: 10.12980/APJTB.4.2014C1312.

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant.

Felix-Silva J, Giordani R, da Silva Jr A, Zucolotto S, Fernandes-Pedrosa M Evid Based Complement Alternat Med. 2014; 2014:369204.

PMID: 25002902 PMC: 4070477. DOI: 10.1155/2014/369204.