Synthesis of 1,2,4-triazines and the Triazinoisoquinolinedione DEF Ring System of Noelaquinone

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2012 Apr 5

PMID 22473572

Authors

Liming Cao

John P Maciejewski

Stephan Elzner

David Amantini

Peter Wipf

Affiliations

Soon will be listed here.

Abstract

The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.

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