» Articles » PMID: 22470199

VDRL Test and Its Interpretation

Overview
Specialty Dermatology
Date 2012 Apr 4
PMID 22470199
Citations 30
Authors
Affiliations
Soon will be listed here.
Abstract

Venereal disease research laboratory (VDRL) test is a nontreponemal test, used for screening of syphilis due to its simplicity, sensitivity and low cost. Prozone phenomenon and biological false positive (BFP) reaction are two shortcomings of this test. Quantitative estimation of VDRL is essential in treatment evaluation. CSF VDRL test is very specific for neurosyphilis though its sensitivity is low. Interpretation of VDRL in HIV infection is incompletely understood.

Citing Articles

Study Protocol for a Yoga-Based Lifestyle Modification Program for Leucorrhea Disorders.

Mittal A, Krishna N, Singh D, Kavuri V Cureus. 2025; 17(1):e78294.

PMID: 40027048 PMC: 11872154. DOI: 10.7759/cureus.78294.


Otosyphilis: A Rare Case of Unilateral Acute Sensorineural Hearing Loss.

Iwata S, Murakawa S, Nishida N, Hato N Cureus. 2025; 17(1):e77338.

PMID: 39935912 PMC: 11813542. DOI: 10.7759/cureus.77338.


The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients.

Zhang R, Zhang X, Du F, Zhou Q, Wu M, Ren J Sci Rep. 2024; 14(1):31171.

PMID: 39732770 PMC: 11682042. DOI: 10.1038/s41598-024-82477-6.


A Loop-Mediated Isothermal Amplification Assay Utilizing Hydroxy Naphthol Blue (LAMP-HNB) for the Detection of Subspp. .

Phurijaruyangkun S, Tangjitrungrot P, Jaratsing P, Augkarawaritsawong S, Kumkrong K, Pongparit S Pathogens. 2024; 13(11).

PMID: 39599503 PMC: 11597873. DOI: 10.3390/pathogens13110949.


Prevalence of Transfusion-Transmissible Infections Among Voluntary Blood Donors in a Tertiary Care Hospital.

Deshmukh S, Rathod Y, Thakore S, Jadhav S Cureus. 2024; 16(9):e70469.

PMID: 39479070 PMC: 11524599. DOI: 10.7759/cureus.70469.


References
1.
Wuepper K, Tuffanelli D . False-positive reaction to VDRL test with prozone phenomena. Association with lymphosarcoma. JAMA. 1966; 195(10):868-9. DOI: 10.1001/jama.1966.03100100120044. View

2.
Hart G . Syphilis tests in diagnostic and therapeutic decision making. Ann Intern Med. 1986; 104(3):368-76. DOI: 10.7326/0003-4819-104-3-368. View

3.
Rolfs R, Joesoef M, Hendershot E, Rompalo A, Augenbraun M, Chiu M . A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med. 1997; 337(5):307-14. DOI: 10.1056/NEJM199707313370504. View

4.
Wiwanitkit V . Biological false reactive VDRL tests: when to re-test?. Southeast Asian J Trop Med Public Health. 2003; 33 Suppl 3:131-2. View

5.
. Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention. MMWR Recomm Rep. 2002; 51(RR-6):1-78. View