Diuretic Use is Associated with Better Learning and Memory in Older Adults in the Ginkgo Evaluation of Memory Study

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2012 Apr 3

PMID 22465175

Citations 9

Authors

Sevil Yasar

Fu-Mei Lin

Linda P Fried

Claudia H Kawas

Kaycee M Sink

Steven T DeKosky

Michelle C Carlson

Affiliations

Soon will be listed here.

Abstract

Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function.

Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function.

Results: In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB use. Potassium-sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (β = 0.068, P = .01; β = 0.094, P < .001) and other antihypertensive medication users (β = 0.080, P = .03; β = 0.153, P < .001). Use of ACE-I or AT2RB was not associated with better cognitive function.

Conclusion: Results warrant further investigation into possible protective effects of potassium-sparing diuretics and the role of potassium in mitigating cognitive decline.

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