The Link Between Angiotensin II-mediated Anxiety and Mood Disorders with NADPH Oxidase-induced Oxidative Stress

Overview

Journal Int J Physiol Pathophysiol Pharmacol

Date 2012 Mar 31

PMID 22461954

Citations 11

Authors

Feng Liu

Jennifer Havens

Qi Yu

Gang Wang

Robin L Davisson

Virginia M Pickel

Costantino Iadecola

Affiliations

Soon will be listed here.

Abstract

The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.

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References

San Jose G, Fortuno A, Moreno M, Robador P, Bidegain J, Varo N . The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension. Clin Sci (Lond). 2008; 116(3):233-40. DOI: 10.1042/CS20080057. View

Saavedra J, Sanchez-Lemus E, Benicky J . Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications. Psychoneuroendocrinology. 2010; 36(1):1-18. PMC: 2998923. DOI: 10.1016/j.psyneuen.2010.10.001. View

Sorce S, Krause K . NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal. 2009; 11(10):2481-504. DOI: 10.1089/ars.2009.2578. View

Andreazza A, Kapczinski F, Kauer-SantAnna M, Walz J, Bond D, Goncalves C . 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder. J Psychiatry Neurosci. 2009; 34(4):263-71. PMC: 2702443. View

Bandelow B, Saleh K, Pauls J, Domschke K, Wedekind D, Falkai P . Insertion/deletion polymorphism in the gene for angiotensin converting enzyme (ACE) in panic disorder: A gender-specific effect?. World J Biol Psychiatry. 2010; 11(1):66-70. DOI: 10.3109/15622970701459810. View

Ohishi M, Dusting G, Fennessy P, Mendelsohn F, Li X, Zhuo J . Increased expression and co-localization of ACE, angiotensin II AT(1) receptors and inducible nitric oxide synthase in atherosclerotic human coronary arteries. Int J Physiol Pathophysiol Pharmacol. 2010; 2(2):111-24. PMC: 3004229. View

Zou Y, Wang F, Feng X, Li W, Pan F, Huang F . Meta-analysis of ACE gene I/D polymorphism and bipolar disorder susceptibility. Nord J Psychiatry. 2011; 65(4):276-82. DOI: 10.3109/08039488.2011.555564. View

Wang G, Milner T, Speth R, Gore A, Wu D, Iadecola C . Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol. 2008; 295(4):R1149-57. PMC: 2576084. DOI: 10.1152/ajpregu.90485.2008. View

Erhardt A, Lucae S, Kern N, Unschuld P, Ising M, Lieb R . Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks. Mol Psychiatry. 2008; 13(3):242-3. DOI: 10.1038/sj.mp.4002094. View

10.

Saxena U . Bioenergetics breakdown in Alzheimer's disease: targets for new therapies. Int J Physiol Pathophysiol Pharmacol. 2011; 3(2):133-9. PMC: 3134007. View

11.

Schiavone S, Sorce S, Dubois-Dauphin M, Jaquet V, Colaianna M, Zotti M . Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry. 2009; 66(4):384-92. DOI: 10.1016/j.biopsych.2009.04.033. View

12.

Kunz M, Gama C, Andreazza A, Salvador M, Cereser K, Gomes F . Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(7):1677-81. DOI: 10.1016/j.pnpbp.2008.07.001. View

13.

Inaba S, Iwai M, Furuno M, Tomono Y, Kanno H, Senba I . Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice. Hypertension. 2008; 53(2):356-62. DOI: 10.1161/HYPERTENSIONAHA.108.123612. View

14.

Ferguson A, Washburn D, Latchford K . Hormonal and neurotransmitter roles for angiotensin in the regulation of central autonomic function. Exp Biol Med (Maywood). 2001; 226(2):85-96. DOI: 10.1177/153537020122600205. View

15.

Cao X, Demel S, Quinn M, Galligan J, Kreulen D . Localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers. Auton Neurosci. 2009; 151(2):90-7. PMC: 2783262. DOI: 10.1016/j.autneu.2009.07.010. View

16.

Shekhar A, Sajdyk T, Gehlert D, Rainnie D . The amygdala, panic disorder, and cardiovascular responses. Ann N Y Acad Sci. 2003; 985:308-25. DOI: 10.1111/j.1749-6632.2003.tb07090.x. View

17.

Sparks D, Hunsaker 3rd J, Amouyel P, Malafosse A, Bellivier F, Leboyer M . Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors. Am J Med Genet B Neuropsychiatr Genet. 2008; 150B(2):290-4. DOI: 10.1002/ajmg.b.30793. View

18.

Steckert A, Valvassori S, Moretti M, Dal-Pizzol F, Quevedo J . Role of oxidative stress in the pathophysiology of bipolar disorder. Neurochem Res. 2010; 35(9):1295-301. DOI: 10.1007/s11064-010-0195-2. View

19.

Helmcke I, Heumuller S, Tikkanen R, Schroder K, Brandes R . Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal. 2008; 11(6):1279-87. DOI: 10.1089/ars.2008.2383. View

20.

Gard P . Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression. Expert Opin Ther Targets. 2004; 8(1):7-14. DOI: 10.1517/14728222.8.1.7. View