Clinical Features of Bipolar Disorder Comorbid with Anxiety Disorders Differ Between Men and Women

Overview

Journal Depress Anxiety

Publisher Wiley

Date 2012 Mar 31

PMID 22461133

Citations 18

Authors

Erika F H Saunders

Kate D Fitzgerald

Peng Zhang

Melvin G McInnis

Affiliations

Soon will be listed here.

Abstract

Background: Anxiety disorders are commonly comorbid with bipolar disorder (BP) and may worsen course of illness, but differential impact of specific anxiety disorders in men and women remains unknown.

Methods: We measured the impact of comorbid panic disorder (PD), social phobia, specific phobia, and obsessive-compulsive disorder (OCD) in 460 women and 276 men with Bipolar I Disorder (BPI) or schizoaffective disorder, bipolar type from the National Institute of Mental Health Bipolar Genetics Initiative. We compared clinical characteristics in BP with and without each anxiety disorder in men and women separately correcting for family relatedness.

Results: Comorbid PD, OCD, and specific phobia were more common in women with BP than men. Comorbid social phobia correlated with increased risk of alcohol abuse in BP women, but not men. Women with comorbid PD attended fewer years of school. Comorbidity with OCD was associated with earlier age at the onset of BP for both genders. Comorbid PD, OCD, and specific phobia were associated with more antidepressant trials in BP, across both genders, compared to BP patients without these anxiety disorders.

Conclusion: In BP, comorbid anxiety disorders are associated with increased risk for functional impairment, and women had differently associated risks than men. Clinicians should be aware of an increased risk for comorbid PD, OCD, and specific phobia in women with BP, and an increased risk of alcohol abuse in women with BD and comorbid social phobia.

Citing Articles

Altered brain regional homogeneity, depressive symptoms, and cognitive impairments in medication-free female patients with current depressive episodes in bipolar disorder and major depressive disorder.

Ni S, Peng T, Gao S, Ling C, Wu F, Jiang J BMC Psychiatry. 2024; 24(1):892.

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Obsessive-Compulsive Disorder as an Epiphenomenon of Comorbid Bipolar Disorder? An Updated Systematic Review.

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Sex Differences in Bipolar Disorders: Impact on Psychopathological Features and Treatment Response.

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Inoue T, Kimura T, Inagaki Y, Shirakawa O Neuropsychiatr Dis Treat. 2020; 16:1695-1704.

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The role of lifetime anxiety history in the course of bipolar spectrum disorders.

Titone M, Freed R, OGarro-Moore J, Gepty A, Ng T, Stange J Psychiatry Res. 2018; 264:202-209.

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