The Oral-systemic Personalized Medicine Model at Marshfield Clinic

Overview

Journal Oral Dis

Specialty Dentistry

Date 2012 Mar 31

PMID 22458294

Citations 9

Authors

I Glurich

A Acharya

S K Shukla

G R Nycz

M H Brilliant

Affiliations

Soon will be listed here.

Abstract

Periodontal disease and diabetes, two diseases that have achieved epidemic status, share a bidirectional relationship driven by micro-inflammatory processes. The present review frames the current understanding of the pathological processes that appear to link these diseases and advances the hypothesis that reversal of the epidemic is possible through application of interdisciplinary intervention and advancement of oral-systemic personalized medicine. An overview of how Marshfield Clinic's unique clinical, informatics and bio-repository resources and infrastructures are being aligned to advance oral-systemic personalized medicine is presented as an interventional model with the potential to reverse the epidemic trends seen for these two chronic diseases over the past several decades. The overall vision is to engineer a transformational shift in paradigm from 'personalized medicine' to 'personalized health'.

Citing Articles

Systematic review of studies examining contribution of oral health variables to risk prediction models for undiagnosed Type 2 diabetes and prediabetes.

Glurich I, Shimpi N, Bartkowiak B, Berg R, Acharya A Clin Exp Dent Res. 2021; 8(1):96-107.

PMID: 34850592 PMC: 8874063. DOI: 10.1002/cre2.515.

Dental services use before and after inpatient admission among privately insured adults in the United States.

Simon L, Barrow J, Starr J, Palmer N J Am Dent Assoc. 2021; 152(12):991-997.

PMID: 34489069 PMC: 8830933. DOI: 10.1016/j.adaj.2021.06.003.

Biochemical and microbiological analysis of the saliva of institutionalized elderly: With edentulism, use of dentures and presence of biofilm.

Montenegro L, Silva E Farias I, de Araujo E, de Pontes J, Raymundo M, de Sousa S J Clin Exp Dent. 2020; 12(7):e632-e637.

PMID: 32905001 PMC: 7462377. DOI: 10.4317/jced.56842.

Integrating Medical-Dental Care for Diabetic Patients: Qualitative Assessment of Provider Perspectives.

Glurich I, Schwei K, Lindberg S, Shimpi N, Acharya A Health Promot Pract. 2017; 19(4):531-541.

PMID: 29073800 PMC: 5878963. DOI: 10.1177/1524839917737752.

The nasal microbiota of dairy farmers is more complex than oral microbiota, reflects occupational exposure, and provides competition for staphylococci.

Shukla S, Ye Z, Sandberg S, Reyes I, Fritsche T, Keifer M PLoS One. 2017; 12(8):e0183898.

PMID: 28850578 PMC: 5574581. DOI: 10.1371/journal.pone.0183898.

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