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I-region Linked Complementing Loci in Resistance to Viral Leukemogenesis in the Mouse

Overview
Journal Immunogenetics
Specialties Allergy & Immunology
Genetics
Date 2012 Mar 31
PMID 22457934
Citations 4
Authors
P Lonai
E Katz
N Haran-Ghera
Affiliations
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Abstract

A-RadLV, a variant of the radiation leukemia virus, inoculated intrathymically into adult mice, causes a high frequency of leukemia in haplotypes b, f, k, d, p and j on the B10 background, whereas H-2s mice are resistant. Resistance is dominant and segregates with H-2s in the offspring of (b x s)b and (b x t2)b backcrosses. Analysis of recombinant strains revealed that resistance is associated with I-A and I-B. B10.A(5R), a recombinant of two sensitive haplotypes, was found to be resistant, suggesting intra-H-2-gene complementation. The resistance of such complementing loci was demonstrated also in the trans position by testing F1 mice bred from sensitive parents. These data are taken to suggest that I-region linked complementing loci, similar to classical Ir genes, may be involved in resistance to murine leukemia.

Citing Articles

Genetic resistance to murine leukemia induced by different radiation leukemia virus variants; a comparative study on the role of the H-2 complex.

Lonai P, Haran-Ghera N Immunogenetics. 1980; 11(1):21-9.

PMID: 7439957 DOI: 10.1007/BF01567766.

H-2-linked regulation of serum gp70 production in mice.

Maruyama N, Lindstrom C Immunogenetics. 1983; 17(5):507-21.

PMID: 6601614 DOI: 10.1007/BF00696874.

Role of the major histocompatibility complex in resistance to viral leukemia; its effect on the preleukemic stage of leukemogenesis.

Lonai P, Katz E, Haran-Ghera N Springer Semin Immunopathol. 1982; 4(4):373-96.

PMID: 6293111 DOI: 10.1007/BF02053740.

H-21-linked control of immunological resistance to viral leukemogenesis as a response to preleukemic cells.

Lonai P, Katz E, Peled A, Haran-Ghera N Immunogenetics. 1981; 12(5-6):423-32.

PMID: 6260638 DOI: 10.1007/BF01561685.

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