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Charcoal Haemoperfusion for Paracetamol Overdose

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 2012 Mar 29
PMID 22454960
Citations 7
Authors
B G Gazzard
R A Willison
M J Weston
R P Thompson
R Williams
Affiliations
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Abstract

1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 No clinical problems were encountered with the technique of haemoperfusion and in particular the drop in blood platelet counts was small (mean fall 16%).

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References
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