The Effects of Meditation on Perceived Stress and Related Indices of Psychological Status and Sympathetic Activation in Persons with Alzheimer's Disease and Their Caregivers: a Pilot Study

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2012 Mar 29

PMID 22454689

Citations 27

Authors

K E Innes

T K Selfe

C J Brown

K M Rose

A Thompson-Heisterman

Affiliations

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Abstract

Objective. To investigate the effects of an 8-week meditation program on perceived stress, sleep, mood, and related outcomes in adults with cognitive impairment and their caregivers. Methods. Community-dwelling adults with a diagnosis of mild cognitive impairment or early-stage Alzheimer's disease, together with their live-in caregivers, were enrolled in the study. After a brief training, participants were asked to meditate for 11 minutes, twice daily for 8 weeks. Major outcomes included measures of perceived stress (Perceived Stress Scale), sleep (General Sleep Disturbance Scale), mood (Profile of Mood States), memory functioning (Memory Functioning Questionnaire), and blood pressure. Participants were assessed pre- and post-intervention. Results. Ten participants (5 of 6 dyads) completed the study. Treatment effects did not vary by participant status; analyses were thus pooled across participants. Adherence was good (meditation sessions completed/week: X = 11.4 ± 1.1). Participants demonstrated improvement in all major outcomes, including perceived stress (P < 0.001), mood (overall, P = 0.07; depression, P = 0.01), sleep (P < 0.04), retrospective memory function (P = 0.04), and blood pressure (systolic, P = 0.004; diastolic, P = 0.065). Conclusions. Findings of this exploratory trial suggest that an 8-week meditation program may offer an acceptable and effective intervention for reducing perceived stress and improving certain domains of sleep, mood, and memory in adults with cognitive impairment and their caregivers.

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References

Franco C, Sola M, Justo E . [Reducing psychological discomfort and overload in Alzheimer's family caregivers through a mindfulness meditation program]. Rev Esp Geriatr Gerontol. 2010; 45(5):252-8. DOI: 10.1016/j.regg.2010.03.006. View

Waelde L, Thompson L, Gallagher-Thompson D . A pilot study of a yoga and meditation intervention for dementia caregiver stress. J Clin Psychol. 2004; 60(6):677-87. DOI: 10.1002/jclp.10259. View

Oken B, Fonareva I, Haas M, Wahbeh H, Lane J, Zajdel D . Pilot controlled trial of mindfulness meditation and education for dementia caregivers. J Altern Complement Med. 2010; 16(10):1031-8. PMC: 3110802. DOI: 10.1089/acm.2009.0733. View

Kang J, Cirrito J, Dong H, Csernansky J, Holtzman D . Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity. Proc Natl Acad Sci U S A. 2007; 104(25):10673-8. PMC: 1965571. DOI: 10.1073/pnas.0700148104. View

Newberg A, Wintering N, Khalsa D, Roggenkamp H, Waldman M . Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: a preliminary study. J Alzheimers Dis. 2010; 20(2):517-26. DOI: 10.3233/JAD-2010-1391. View

Beaulieu-Bonneau S, Hudon C . Sleep disturbances in older adults with mild cognitive impairment. Int Psychogeriatr. 2009; 21(4):654-66. DOI: 10.1017/S1041610209009120. View

Cohen B, Panguluri P, Na B, Whooley M . Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study. Psychiatry Res. 2009; 175(1-2):133-7. PMC: 2867840. DOI: 10.1016/j.psychres.2009.02.004. View

Ryan K, Weldon A, Huby N, Persad C, Bhaumik A, Heidebrink J . Caregiver support service needs for patients with mild cognitive impairment and Alzheimer disease. Alzheimer Dis Assoc Disord. 2009; 24(2):171-6. PMC: 2877755. DOI: 10.1097/WAD.0b013e3181aba90d. View

Lu Y, Austrom M, Perkins S, Bakas T, Farlow M, He F . Depressed mood in informal caregivers of individuals with mild cognitive impairment. Am J Alzheimers Dis Other Demen. 2007; 22(4):273-85. PMC: 10846019. DOI: 10.1177/1533317507301367. View

10.

McEwen B . Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging. 2002; 23(5):921-39. DOI: 10.1016/s0197-4580(02)00027-1. View

11.

Kilander L, Nyman H, Boberg M, Hansson L, Lithell H . Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men. Hypertension. 1998; 31(3):780-6. DOI: 10.1161/01.hyp.31.3.780. View

12.

Tremont G . Family caregiving in dementia. Med Health R I. 2011; 94(2):36-8. PMC: 3487163. View

13.

Luppino F, de Wit L, Bouvy P, Stijnen T, Cuijpers P, Penninx B . Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010; 67(3):220-9. DOI: 10.1001/archgenpsychiatry.2010.2. View

14.

Logsdon R, Teri L . The Pleasant Events Schedule-AD: psychometric properties and relationship to depression and cognition in Alzheimer's disease patients. Gerontologist. 1997; 37(1):40-5. DOI: 10.1093/geront/37.1.40. View

15.

Epstein-Lubow G, Miller I, McBee L . Mindfulness training for caregivers. Psychiatr Serv. 2006; 57(3):421. DOI: 10.1176/appi.ps.57.3.421. View

16.

Lane J, Seskevich J, Pieper C . Brief meditation training can improve perceived stress and negative mood. Altern Ther Health Med. 2007; 13(1):38-44. View

17.

Rosenberg P, Mielke M, Appleby B, Oh E, Leoutsakos J, Lyketsos C . Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatry. 2010; 26(4):364-72. PMC: 3204866. DOI: 10.1002/gps.2535. View

18.

von Kanel R, Mausbach B, Patterson T, Dimsdale J, Aschbacher K, Mills P . Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controls. Gerontology. 2008; 54(3):131-7. DOI: 10.1159/000113649. View

19.

Winter Y, Korchounov A, Zhukova T, Bertschi N . Depression in elderly patients with Alzheimer dementia or vascular dementia and its influence on their quality of life. J Neurosci Rural Pract. 2011; 2(1):27-32. PMC: 3122998. DOI: 10.4103/0976-3147.80087. View

20.

Caswell L, Vitaliano P, Croyle K, Scanlan J, Zhang J, Daruwala A . Negative associations of chronic stress and cognitive performance in older adult spouse caregivers. Exp Aging Res. 2003; 29(3):303-18. DOI: 10.1080/03610730303721. View