Inositol Phosphate Release and Steroidogenesis in Rat Adrenal Glomerulosa Cells. Comparison of the Effects of Endothelin, Angiotensin II and Vasopressin

Overview

Journal Biochem J

Specialty Biochemistry

Date 1990 Nov 1

PMID 2244879

Citations 5

Authors

E A Woodcock

P J Little

J K Tanner

Affiliations

Soon will be listed here.

Abstract

Endothelin has steroidogenic activity in adrenal glomerulosa cells, as do two other vasoconstrictor peptides, angiotensin II and vasopressin. The steroidogenic activities of angiotensin II and vasopressin are probably mediated via the phosphatidylinositol-turnover pathway and associated changes in cytosolic Ca2+ concentration. Endothelin caused a steroidogenic response, which was small compared with that to angiotensin II and quantitatively similar to the vasopressin response. Cytosolic free Ca2+ responses were similarly higher to angiotensin II than to either of the other two peptides. However, total inositol phosphate responses to endothelin and angiotensin II were similar when these were measured over 20 min, and were quantitatively greater than the vasopressin response. A detailed study has been made of the phosphatidylinositol-turnover response to endothelin in comparison with responses to angiotensin II and vasopressin. Each of the three peptides produced a rapid and transient rise in Ins(1,4,5)P3 (max. 5-15 s), followed by a slow sustained rise. Ins(1,4,5)P3 was metabolized by both dephosphorylation and phosphorylation pathways, but the relative importance of the two metabolic pathways was different under stimulation by each of the three peptides. These findings show that adrenal glomerulosa cells can distinguish between the stimulation of phosphatidylinositol turnover by three different effectors. These differences in the pathway may be associated with the observed different steroidogenic and Ca2+ responses to the three peptides.

Citing Articles

Regulation of blood pressure and salt homeostasis by endothelin.

Kohan D, Rossi N, Inscho E, Pollock D Physiol Rev. 2011; 91(1):1-77.

PMID: 21248162 PMC: 3236687. DOI: 10.1152/physrev.00060.2009.

Endothelin signaling pathways in rat adrenal medulla.

Anita I, Yaira M, Maria del Rosario G Cell Mol Neurobiol. 2006; 26(4-6):703-18.

PMID: 16897361 PMC: 11881819. DOI: 10.1007/s10571-006-9111-3.

Inhibition of endothelin- and phorbol ester-stimulated tyrosine kinase activity by corticotrophin in the rat adrenal zona glomerulosa.

Kapas S, Hinson J Biochem J. 1996; 313 ( Pt 3):867-72.

PMID: 8611168 PMC: 1216991. DOI: 10.1042/bj3130867.

Evidence for phosphatidylinositol hydrolysis in pancreatic islets stimulated with carbamoylcholine. Kinetic analysis of inositol polyphosphate metabolism.

Biden T, Prugue M, Davison A Biochem J. 1992; 285 ( Pt 2):541-9.

PMID: 1637344 PMC: 1132822. DOI: 10.1042/bj2850541.

Different pathways of inositol phosphate metabolism in intact neonatal rat hearts and isolated cardiomyocytes.

Woodcock E, Tanner J, Fullerton M, Kuraja I Biochem J. 1992; 281 ( Pt 3):683-8.

PMID: 1536648 PMC: 1130745. DOI: 10.1042/bj2810683.

References

Marie J, Jard S . Angiotensin II inhibits adenylate cyclase from adrenal cortex glomerulosa zone. FEBS Lett. 1983; 159(1-2):97-101. DOI: 10.1016/0014-5793(83)80424-4. View

Harris A, Thompson B, Taylor P, Sklar L . An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature. 1988; 334(6180):353-6. DOI: 10.1038/334353a0. View

Kojima I, Lippes H, Kojima K, Rasmussen H . Aldosterone secretion: effect of phorbol ester and A23187. Biochem Biophys Res Commun. 1983; 116(2):555-62. DOI: 10.1016/0006-291x(83)90559-4. View

Burgess G, Godfrey P, McKinney J, Berridge M, Irvine R, Putney Jr J . The second messenger linking receptor activation to internal Ca release in liver. Nature. 1984; 309(5963):63-6. DOI: 10.1038/309063a0. View

Biden T, Prentki M, Irvine R, Berridge M, Wollheim C . Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells. Biochem J. 1984; 223(2):467-73. PMC: 1144320. DOI: 10.1042/bj2230467. View

Grynkiewicz G, Poenie M, Tsien R . A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985; 260(6):3440-50. View

Kojima I, Kojima K, Rasmussen H . Role of calcium fluxes in the sustained phase of angiotensin II-mediated aldosterone secretion from adrenal glomerulosa cells. J Biol Chem. 1985; 260(16):9177-84. View

Aguilera G, Catt K . Participation of voltage-dependent calcium channels in the regulation of adrenal glomerulosa function by angiotensin II and potassium. Endocrinology. 1986; 118(1):112-8. DOI: 10.1210/endo-118-1-112. View

Woodcock E, McLeod J, Johnston C . Vasopressin stimulates phosphatidylinositol turnover and aldosterone synthesis in rat adrenal glomerulosa cells: comparison with angiotensin II. Endocrinology. 1986; 118(6):2432-6. DOI: 10.1210/endo-118-6-2432. View

10.

Griendling K, Rittenhouse S, Brock T, Ekstein L, Gimbrone Jr M, Alexander R . Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem. 1986; 261(13):5901-6. View

11.

Aiyar N, Nambi P, Stassen F, Crooke S . Vascular vasopressin receptors mediate phosphatidylinositol turnover and calcium efflux in an established smooth muscle cell line. Life Sci. 1986; 39(1):37-45. DOI: 10.1016/0024-3205(86)90435-2. View

12.

NISHIZUKA Y . Studies and perspectives of protein kinase C. Science. 1986; 233(4761):305-12. DOI: 10.1126/science.3014651. View

13.

Kojima I, Shibata H, Ogata E . Pertussis toxin blocks angiotensin II-induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell. FEBS Lett. 1986; 204(2):347-51. DOI: 10.1016/0014-5793(86)80841-9. View

14.

Biden T, Wollheim C . Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells. J Biol Chem. 1986; 261(26):11931-4. View

15.

Hirata Y, Yoshimi H, Takata S, Watanabe T, Kumagai S, Nakajima K . Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. Biochem Biophys Res Commun. 1988; 154(3):868-75. DOI: 10.1016/0006-291x(88)90220-3. View

16.

Horstman D, Takemura H, Putney Jr J . Formation and metabolism of [3H]inositol phosphates in AR42J pancreatoma cells. Substance P-induced Ca2+ mobilization in the apparent absence of inositol 1,4,5-trisphosphate 3-kinase activity. J Biol Chem. 1988; 263(30):15297-303. View

17.

Guillon G, Gallo-Payet N, Balestre M, Lombard C . Cholera-toxin and corticotropin modulation of inositol phosphate accumulation induced by vasopressin and angiotensin II in rat glomerulosa cells. Biochem J. 1988; 253(3):765-75. PMC: 1149369. DOI: 10.1042/bj2530765. View

18.

Pijuan V, Litosch I . Norepinephrine stimulates the production of inositol trisphosphate and inositol tetrakisphosphate in rat aorta. Biochem Biophys Res Commun. 1988; 156(1):240-5. DOI: 10.1016/s0006-291x(88)80831-3. View

19.

Hill T, Dean N, Boynton A . Inositol 1,3,4,5-tetrakisphosphate induces Ca2+ sequestration in rat liver cells. Science. 1988; 242(4882):1176-8. DOI: 10.1126/science.2847317. View

20.

Van Renterghem C, VIGNE P, Barhanin J, Schmid-Alliana A, Frelin C, Lazdunski M . Molecular mechanism of action of the vasoconstrictor peptide endothelin. Biochem Biophys Res Commun. 1988; 157(3):977-85. DOI: 10.1016/s0006-291x(88)80970-7. View