Oxidative Stress Level in the Testes of Mice and Rats During Nickel Intoxication

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2012 Mar 27

PMID 22448131

Citations 3

Authors

Eugenia Murawska-Cialowicz

Wojciech Bal

Lidia Januszewska

Marcin Zawadzki

Joanna Rychel

Jolanta Zuwala-Jagiello

Affiliations

Soon will be listed here.

Abstract

The genotioxic and carcinogenic effect of nickel probably results from its capacity to produce reactive oxygen species (ROS) and disturb the redox balance. The aim of the study was to find out if rats lacking spermatic protamine 2 are less susceptible to Ni(II) than mice. Consequently, the levels of malondialdehyde + 4 hydroxynonenal (MDA+4HDA) - markers of lipid peroxidation, as well as the level of reduced glutathione (GSH) were measured within the rat and mouse testes. Our results showed that the levels of lipid peroxidation markers were elevated in testicular homogenates of intoxicated mice without any changes in rats. GSH level was lower in the group of intoxicated mice comparing to the control without statistically significant changes in rats' homogenates. Moreover, the level of GSH in the testes of intoxicated mice was lower than in rats. On the basis of our results, it appears that Ni(II) can initiate oxidative stress in the testes of mice but not of rats and can reduce GSH level. Consequently, the antioxidative defense of the testes is reduced. Ni(II) that causes oxidative stress in the testes may also contribute to infertility.

Citing Articles

A Molecular Mechanism to Explain the Nickel-Induced Changes in Protamine-like Proteins and Their DNA Binding Affecting Sperm Chromatin in : An In Vitro Study.

Carbone G, Lettieri G, Marinaro C, Costabile M, Notariale R, Bianchi A Biomolecules. 2023; 13(3).

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Update of the risk assessment of nickel in food and drinking water.

Schrenk D, Bignami M, Bodin L, Chipman J, Del Mazo J, Grasl-Kraupp B EFSA J. 2020; 18(11):e06268.

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Hormonal Perturbations in Occupationally Exposed Nickel Workers.

Beshir S, Ibrahim K, Shaheen W, Shahy E Open Access Maced J Med Sci. 2016; 4(2):307-11.

PMID: 27335607 PMC: 4908752. DOI: 10.3889/oamjms.2016.046.

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