Clinicopathologic Study of Parapharyngeal Tumors

Overview

Journal J Cytol

Specialty Cell Biology

Date 2012 Mar 23

PMID 22438613

Citations 4

Authors

Mimi Gangopadhyay

Arghya Bandopadhyay

Swapan Sinha

Subrato Chakroborty

Affiliations

Soon will be listed here.

Abstract

Background: Parapharyngeal space (PPS) tumors are rare. Three main groups are identified, namely those of salivary origin, neurogenic tumors and paragangliomas. Early pathological classification of PPS tumors is important for pin point diagnosis and timely management.

Aims: The PPS is a complex anatomical potential space and poses high risk of per and postoperative complication. This study was done to perform optimum preoperative evaluation by clinicoradiologic correlation and guided fine needle aspiration cytology (FNAC) which is essential to minimize intraoperative risk.

Materials And Methods: Guided FNAC was carried out to diagnose parapharyngeal tumors in 48 patients from January 2008 to January 2010. The inflammatory lesions were excluded in the present study. Correlation with histopathology was done in all the cases.

Results: The mean age for all the patients was 38.2 years. There were 23 male and 25 female subjects. Seventy nine percent of the lesions were benign with pleomorphic salivary adenoma being the commonest, while only 20.8% of the lesions were malignant. All the patients presented with neck swelling. No complication was encountered in the present study.

Conclusion: FNAC can replace incisional biopsy which may be hazardous in this area. Immediate treatment can be planned based on the FNAC report.

Citing Articles

[Research progress in the anatomy and surgical approach of the parapharyngeal space].

Xue K, Wang L, Zheng S, Zhang H, Liu Q, Gu Y Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024; 38(6):534-540.

PMID: 38858121 PMC: 11480582. DOI: 10.13201/j.issn.2096-7993.2024.06.015.

Primary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls.

Bulut O, Giger R, Alwagdani A, Aldabal N, Stenzinger A, Heimgartner S Eur Arch Otorhinolaryngol. 2021; 278(12):4933-4941.

PMID: 33740083 PMC: 8553685. DOI: 10.1007/s00405-021-06718-4.

Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.

Locketz G, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M Eur Arch Otorhinolaryngol. 2015; 273(3):727-34.

PMID: 25708410 DOI: 10.1007/s00405-015-3545-5.

Myoepithelial cell-rich pleormorphic adenoma of minor salivary gland of parapharyngeal space.

Rawat D, Sonkhya D, Sonkhya N, Gupta S Case Rep Otolaryngol. 2012; 2012:537381.

PMID: 22957285 PMC: 3432331. DOI: 10.1155/2012/537381.

References

Qureshi S, Shet T, Nagarajan G, DCruz A . Extranodal non-Hodgkin's lymphoma of the parapharyngeal space. Indian J Med Sci. 2006; 60(4):159-61. View

SPIRO R, Huvos A, Strong E . Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases. Am J Surg. 1974; 128(4):512-20. DOI: 10.1016/0002-9610(74)90265-7. View

Bass R . Approaches to the diagnosis and treatment of tumors of the parapharyngeal space. Head Neck Surg. 1982; 4(4):281-9. DOI: 10.1002/hed.2890040404. View

Hughes 3rd K, Olsen K, McCaffrey T . Parapharyngeal space neoplasms. Head Neck. 1995; 17(2):124-30. DOI: 10.1002/hed.2880170209. View

Mondal A, Raychoudhuri B . Peroral fine needle aspiration cytology of parapharyngeal lesions. Acta Cytol. 1993; 37(5):694-8. View

Hunink M, De Slegte R, Gerritsen G, Speelman H . CT and MR assessment of tumors of the nose and paranasal sinuses, the nasopharynx and the parapharyngeal space using ROC methodology. Neuroradiology. 1990; 32(3):220-5. DOI: 10.1007/BF00589116. View

Tak B, Bhuie H, Gupta A . Para pharyngeal space tumors : An overview. Indian J Otolaryngol Head Neck Surg. 2012; 53(2):173-5. PMC: 3450851. DOI: 10.1007/BF02991520. View

Pang K, Goh C, Tan H . Parapharyngeal space tumours: an 18 year review. J Laryngol Otol. 2002; 116(3):170-5. DOI: 10.1258/0022215021910447. View

Mondal P, Basu N, Gupta S, Bhattacharya N, Mallick M . Fine needle aspiration cytology of parapharyngeal tumors. J Cytol. 2011; 26(3):102-4. PMC: 3168009. DOI: 10.4103/0970-9371.59395. View

10.

Whyte A, Hourihan M . The diagnosis of tumours involving the parapharyngeal space by computed tomography. Br J Radiol. 1989; 62(738):526-31. DOI: 10.1259/0007-1285-62-738-526. View

11.

Thunnissen F, Peterse J, Buchholtz R, van der Beek J, Bosman F . Polyploidy in pleomorphic adenomas with cytological atypia. Cytopathology. 1992; 3(2):101-9. DOI: 10.1111/j.1365-2303.1992.tb00032.x. View

12.

Som P, Biller H, Lawson W . Tumors of the parapharyngeal space: preoperative evaluation, diagnosis and surgical approaches. Ann Otol Rhinol Laryngol Suppl. 1981; 90(1 Pt 4):3-15. DOI: 10.1177/00034894810901s301. View

13.

Park C, Suh K, Kim C . Neurilemmomas of the cervical vagus nerve. Head Neck. 1991; 13(5):439-41. DOI: 10.1002/hed.2880130512. View

14.

Luna-Ortiz K, Navarrete-Aleman J, Granados-Garcia M, Herrera-Gomez A . Primary parapharyngeal space tumors in a Mexican cancer center. Otolaryngol Head Neck Surg. 2005; 132(4):587-91. DOI: 10.1016/j.otohns.2005.01.013. View

15.

Shoss S, Donovan D, ALFORD B . Tumors of the parapharyngeal space. Arch Otolaryngol. 1985; 111(11):753-7. DOI: 10.1001/archotol.1985.00800130085011. View

16.

Jackel M . [Anatomic variants of the internal carotid artery as differential parapharyngeal space-occupying lesions diagnosis]. HNO. 1998; 45(12):1018-21. DOI: 10.1007/s001060050187. View