Gestational Weight Gain and Predicted Changes in Offspring Anthropometrics Between Early Infancy and 3 Years

Methods: Women with singleton infants were recruited from the third cohort of the Pregnancy, Infection, and Nutrition Study (2001-2005). Term infants with at least one weight or length measurement during the study period were included (n = 476). Multivariable linear mixed effects regression models estimated longitudinal changes in WAZ, LAZ and WLZ associated with GWG.

Results: In early infancy, compared with infants of women with adequate weight gain, those of women with excessive weight gains had higher WAZ, LAZ and WLZ. Excessive GWG ≥ 200% of the recommended amount was associated with faster rates of change in WAZ and LAZ and noticeably higher predicted mean WAZ and WLZ that persisted across the study period.

Conclusions: GWG is associated with significant differences in offspring anthropometrics in early infancy that persisted to 3 years of age. More longitudinal studies that utilize maternal and paediatric body composition measures are necessary to understand the nature of this association.

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References

Hull H, Thornton J, Ji Y, Paley C, Rosenn B, Mathews P . Higher infant body fat with excessive gestational weight gain in overweight women. Am J Obstet Gynecol. 2011; 205(3):211.e1-7. PMC: 3170486. DOI: 10.1016/j.ajog.2011.04.004. View

Hull H, Dinger M, Knehans A, Thompson D, Fields D . Impact of maternal body mass index on neonate birthweight and body composition. Am J Obstet Gynecol. 2008; 198(4):416.e1-6. DOI: 10.1016/j.ajog.2007.10.796. View

Crozier S, Inskip H, Godfrey K, Cooper C, Harvey N, Cole Z . Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey. Am J Clin Nutr. 2010; 91(6):1745-51. PMC: 3091013. DOI: 10.3945/ajcn.2009.29128. View

McMillen I, Adam C, Muhlhausler B . Early origins of obesity: programming the appetite regulatory system. J Physiol. 2005; 565(Pt 1):9-17. PMC: 1464497. DOI: 10.1113/jphysiol.2004.081992. View

Latzer Y, Edmunds L, Fenig S, Golan M, Gur E, Hochberg Z . Managing childhood overweight: behavior, family, pharmacology, and bariatric surgery interventions. Obesity (Silver Spring). 2009; 17(3):411-23. DOI: 10.1038/oby.2008.553. View

Laird N, Ware J . Random-effects models for longitudinal data. Biometrics. 1982; 38(4):963-74. View

Oken E, Taveras E, Kleinman K, Rich-Edwards J, Gillman M . Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol. 2007; 196(4):322.e1-8. PMC: 1899090. DOI: 10.1016/j.ajog.2006.11.027. View

Catalano P, Ehrenberg H . The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG. 2006; 113(10):1126-33. DOI: 10.1111/j.1471-0528.2006.00989.x. View

Rising R, Lifshitz F . Relationship between maternal obesity and infant feeding-interactions. Nutr J. 2005; 4:17. PMC: 1156942. DOI: 10.1186/1475-2891-4-17. View

10.

Pietilainen K, Kaprio J, Rasanen M, Winter T, Rissanen A, Rose R . Tracking of body size from birth to late adolescence: contributions of birth length, birth weight, duration of gestation, parents' body size, and twinship. Am J Epidemiol. 2001; 154(1):21-9. DOI: 10.1093/aje/154.1.21. View

11.

Jain N, Denk C, Kruse L, Dandolu V . Maternal obesity: can pregnancy weight gain modify risk of selected adverse pregnancy outcomes?. Am J Perinatol. 2007; 24(5):291-8. DOI: 10.1055/s-2007-981432. View

12.

Nguyen V, Larson D, Johnson R, Goran M . Fat intake and adiposity in children of lean and obese parents. Am J Clin Nutr. 1996; 63(4):507-13. DOI: 10.1093/ajcn/63.4.507. View

13.

Druet C, Ong K . Early childhood predictors of adult body composition. Best Pract Res Clin Endocrinol Metab. 2008; 22(3):489-502. DOI: 10.1016/j.beem.2008.02.002. View

14.

Stuebe A, Oken E, Gillman M . Associations of diet and physical activity during pregnancy with risk for excessive gestational weight gain. Am J Obstet Gynecol. 2009; 201(1):58.e1-8. PMC: 2706304. DOI: 10.1016/j.ajog.2009.02.025. View

15.

Rifas-Shiman S, Rich-Edwards J, Scanlon K, Kleinman K, Gillman M . Misdiagnosis of overweight and underweight children younger than 2 years of age due to length measurement bias. MedGenMed. 2006; 7(4):56. PMC: 1488725. View

16.

Mehta U, Siega-Riz A, Herring A . Effect of body image on pregnancy weight gain. Matern Child Health J. 2010; 15(3):324-32. PMC: 3665282. DOI: 10.1007/s10995-010-0578-7. View

17.

Sewell M, Huston-Presley L, Super D, Catalano P . Increased neonatal fat mass, not lean body mass, is associated with maternal obesity. Am J Obstet Gynecol. 2006; 195(4):1100-3. DOI: 10.1016/j.ajog.2006.06.014. View

18.

Ay L, Kruithof C, Bakker R, Steegers E, Witteman J, Moll H . Maternal anthropometrics are associated with fetal size in different periods of pregnancy and at birth. The Generation R Study. BJOG. 2009; 116(7):953-63. DOI: 10.1111/j.1471-0528.2009.02143.x. View

19.

Carpenter M, Coustan D . Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol. 1982; 144(7):768-73. DOI: 10.1016/0002-9378(82)90349-0. View

20.

Ogden C, Carroll M, Curtin L, Lamb M, Flegal K . Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA. 2010; 303(3):242-9. DOI: 10.1001/jama.2009.2012. View