Dynamic Contrast-enhanced Imaging Techniques: CT and MRI

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2012 Mar 22

PMID 22433822

Citations 84

Authors

J P B OConnor

P S Tofts

K A Miles

L M Parkes

G Thompson

A Jackson

Affiliations

Soon will be listed here.

Abstract

Over the last few decades there has been considerable research into quantifying the cerebral microvasculature with imaging, for use in studies of the human brain and various pathologies including cerebral tumours. This review highlights key issues in dynamic contrast-enhanced CT, dynamic contrast-enhanced MRI and arterial spin labelling, the various applications of which are considered elsewhere in this special issue of the British Journal of Radiology.

Citing Articles

Translation of dynamic contrast-enhanced imaging onto a magnetic resonance-guided linear accelerator in patients with head and neck cancer.

Dubec M, Berks M, Price J, McDaid L, Gaffney J, Little R Phys Imaging Radiat Oncol. 2025; 33():100689.

PMID: 39802650 PMC: 11721217. DOI: 10.1016/j.phro.2024.100689.

Performance evaluation of a 4D similarity filter for dynamic CT angiography imaging of the liver.

Tunissen S, Smit E, Mikerov M, Prokop M, Sechopoulos I Med Phys. 2024; 51(12):8814-8827.

PMID: 39264288 PMC: 11656287. DOI: 10.1002/mp.17394.

Review of tracer kinetic models in evaluation of gliomas using dynamic contrast-enhanced imaging.

Zhou J, Hou Z, Tian C, Zhu Z, Ye M, Chen S Front Oncol. 2024; 14:1380793.

PMID: 38947892 PMC: 11211364. DOI: 10.3389/fonc.2024.1380793.

Predicting cytogenetic risk in multiple myeloma using conventional whole-body MRI, spinal dynamic contrast-enhanced MRI, and spinal diffusion-weighted imaging.

Den Berghe T, Verberckmoes B, Kint N, Wallaert S, De Vos N, Algoet C Insights Imaging. 2024; 15(1):106.

PMID: 38597979 PMC: 11006637. DOI: 10.1186/s13244-024-01672-1.

Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration.

Sanvito F, Kaufmann T, Cloughesy T, Wen P, Ellingson B Front Radiol. 2023; 3:1267615.

PMID: 38152383 PMC: 10751345. DOI: 10.3389/fradi.2023.1267615.

References

Calamante F, Thomas D, Pell G, Wiersma J, Turner R . Measuring cerebral blood flow using magnetic resonance imaging techniques. J Cereb Blood Flow Metab. 1999; 19(7):701-35. DOI: 10.1097/00004647-199907000-00001. View

Detre J, Leigh J, Williams D, Koretsky A . Perfusion imaging. Magn Reson Med. 1992; 23(1):37-45. DOI: 10.1002/mrm.1910230106. View

Batchelor T, Duda D, Tomaso E, Ancukiewicz M, Plotkin S, Gerstner E . Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010; 28(17):2817-23. PMC: 2903316. DOI: 10.1200/JCO.2009.26.3988. View

Alsop D, Detre J . Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab. 1996; 16(6):1236-49. DOI: 10.1097/00004647-199611000-00019. View

Parkes L, Tofts P . Improved accuracy of human cerebral blood perfusion measurements using arterial spin labeling: accounting for capillary water permeability. Magn Reson Med. 2002; 48(1):27-41. DOI: 10.1002/mrm.10180. View

Li K, Zhu X, Jackson A . Parametric mapping of scaled fitting error in dynamic susceptibility contrast enhanced MR perfusion imaging. Br J Radiol. 2000; 73(869):470-81. DOI: 10.1259/bjr.73.869.10884742. View

Jackson A, Kassner A, Annesley-Williams D, Reid H . Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade. AJNR Am J Neuroradiol. 2002; 23(1):7-14. PMC: 7975509. View

Luh W, Wong E, Bandettini P, Hyde J . QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn Reson Med. 1999; 41(6):1246-54. DOI: 10.1002/(sici)1522-2594(199906)41:6<1246::aid-mrm22>3.0.co;2-n. View

OConnor J, Carano R, Clamp A, Ross J, Ho C, Jackson A . Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. Clin Cancer Res. 2009; 15(21):6674-82. PMC: 4688942. DOI: 10.1158/1078-0432.CCR-09-0731. View

10.

Miles K, Griffiths M . Perfusion CT: a worthwhile enhancement?. Br J Radiol. 2003; 76(904):220-31. DOI: 10.1259/bjr/13564625. View

11.

Kim H, Kim S, Kim J . Underestimation of cerebral perfusion on flow-sensitive alternating inversion recovery image: semiquantitative evaluation with time-to-peak values. AJNR Am J Neuroradiol. 2007; 28(10):2008-13. PMC: 8134235. DOI: 10.3174/ajnr.A0720. View

12.

Jackson A, OConnor J, Thompson G, Mills S . Magnetic resonance perfusion imaging in neuro-oncology. Cancer Imaging. 2008; 8:186-99. PMC: 2590875. DOI: 10.1102/1470-7330.2008.0019. View

13.

Tofts P, Brix G, Buckley D, Evelhoch J, Henderson E, Knopp M . Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999; 10(3):223-32. DOI: 10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s. View

14.

Provenzale J, Wang G, Brenner T, Petrella J, Sorensen A . Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging. AJR Am J Roentgenol. 2002; 178(3):711-6. DOI: 10.2214/ajr.178.3.1780711. View

15.

Jackson A, OConnor J, Parker G, Jayson G . Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging. Clin Cancer Res. 2007; 13(12):3449-59. DOI: 10.1158/1078-0432.CCR-07-0238. View

16.

Ostergaard L, Johannsen P, Vestergaard-Poulsen P, Asboe H, Gee A, Hansen S . Cerebral blood flow measurements by magnetic resonance imaging bolus tracking: comparison with [(15)O]H2O positron emission tomography in humans. J Cereb Blood Flow Metab. 1998; 18(9):935-40. DOI: 10.1097/00004647-199809000-00002. View

17.

Buxton R, Uludag K, Dubowitz D, Liu T . Modeling the hemodynamic response to brain activation. Neuroimage. 2004; 23 Suppl 1:S220-33. DOI: 10.1016/j.neuroimage.2004.07.013. View

18.

Brown G, Clark C, Liu T . Measurement of cerebral perfusion with arterial spin labeling: Part 2. Applications. J Int Neuropsychol Soc. 2007; 13(3):526-38. PMC: 2408863. DOI: 10.1017/S1355617707070634. View

19.

Barrett T, Brechbiel M, Bernardo M, Choyke P . MRI of tumor angiogenesis. J Magn Reson Imaging. 2007; 26(2):235-49. DOI: 10.1002/jmri.20991. View

20.

Buckley D, Kerslake R, Blackband S, Horsman A . Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure. Magn Reson Med. 1994; 32(5):646-51. DOI: 10.1002/mrm.1910320514. View