Local Delivery of Nitric Oxide: Targeted Delivery of Therapeutics to Bone and Connective Tissues

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2012 Mar 22

PMID 22433782

Citations 36

Authors

Scott P Nichols

Wesley L Storm

Ahyeon Koh

Mark H Schoenfisch

Affiliations

Soon will be listed here.

Abstract

Non-invasive treatment of injuries and disorders affecting bone and connective tissue remains a significant challenge facing the medical community. A treatment route that has recently been proposed is nitric oxide (NO) therapy. Nitric oxide plays several important roles in physiology with many conditions lacking adequate levels of NO. As NO is a radical, localized delivery via NO donors is essential to promoting biological activity. Herein, we review current literature related to therapeutic NO delivery in the treatment of bone, skin and tendon repair.

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