Male Gender Bias in Autism and Pediatric Autoimmunity
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Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease.
Maternal inflammation and its ramifications on fetal neurodevelopment.
Kwon H, Choi G, Huh J Trends Immunol. 2022; 43(3):230-244.
PMID: 35131181 PMC: 9005201. DOI: 10.1016/j.it.2022.01.007.
Xiang D, Lu J, Wei C, Cai X, Wang Y, Liang Y Front Cell Neurosci. 2020; 14:87.
PMID: 32327976 PMC: 7161090. DOI: 10.3389/fncel.2020.00087.
Haida O, Al Sagheer T, Balbous A, Francheteau M, Matas E, Soria F Transl Psychiatry. 2019; 9(1):124.
PMID: 30923308 PMC: 6438965. DOI: 10.1038/s41398-019-0457-y.
Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease.
Kwon Y, Kim J, Yun S, Yu J, Yoon K, Lee K PLoS One. 2017; 12(9):e0184248.
PMID: 28886140 PMC: 5590908. DOI: 10.1371/journal.pone.0184248.
Translational toxicology: a developmental focus for integrated research strategies.
Hughes C, Waters M, Allen D, Obasanjo I BMC Pharmacol Toxicol. 2013; 14:51.
PMID: 24079609 PMC: 3850030. DOI: 10.1186/2050-6511-14-51.