Regulation of Inflammasome Signaling

Overview

Journal Nat Immunol

Date 2012 Mar 21

PMID 22430786

Citations 499

Authors

Vijay A K Rathinam

Sivapriya Kailasan Vanaja

Katherine A Fitzgerald

Affiliations

Soon will be listed here.

Abstract

Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1β (IL-1β), IL-18 and pyroptosis. Inflammasomes recognize microbial products or endogenous molecules released from damaged or dying cells both through direct binding of ligands and indirect mechanisms. The potential of the IL-1 family of cytokines to cause tissue damage and chronic inflammation emphasizes the importance of regulating inflammasomes. Many regulatory mechanisms have been identified that act as checkpoints for attenuating inflammasome signaling at multiple steps. Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance.

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