Intercellular Cross-talk Among Bone Cells: New Factors and Pathways

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2012 Mar 20

PMID 22427140

Citations 54

Authors

Natalie A Sims

Nicole C Walsh

Affiliations

Soon will be listed here.

Abstract

Intercellular communication within the bone microenvironment is critical for the maintenance of normal bone structure. Osteoblast-lineage cells at all stages of differentiation, from pluripotent precursors to matrix-embedded osteocytes, produce regulatory factors that modulate the differentiation and activity of both bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoclasts can also release factors that feed back to regulate osteoblast activity. Intercellular cross-talk within the bone microenvironment is not restricted only to these bone cells. Other cells within the bone marrow microenvironment, including adipocytes, T cells, and macrophages, play key roles that influence the processes of bone formation and resorption. This review discusses recent work that provides new insights into some of these communication networks and the factors involved, including osteocytic production of receptor activator of nuclear factor-κB ligand (RANKL) and sclerostin, osteoblastic production of interleukin-33, osteoclast-derived Semaphorin 4D, ephrin signaling, and signals from T helper cells and resident osteal macrophages (osteomacs).

Citing Articles

Single-cell RNA sequencing reveals multiple immune cell subpopulations promote the formation of abnormal bone microenvironment in osteoporosis.

Yang W, Wang Y, Mo K, Chen W, Xie X Sci Rep. 2024; 14(1):29493.

PMID: 39604551 PMC: 11603148. DOI: 10.1038/s41598-024-80993-z.

Potential drug targets for osteoporosis identified: A Mendelian randomization study.

Zhao G, Wang Q, Duan N, Zhang K, Li Z, Sun L Heliyon. 2024; 10(16):e36566.

PMID: 39253131 PMC: 11382026. DOI: 10.1016/j.heliyon.2024.e36566.

Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology.

Li S, Liu G, Hu S Front Immunol. 2024; 15:1396122.

PMID: 38817601 PMC: 11137183. DOI: 10.3389/fimmu.2024.1396122.

Mesenchymal Stem Cell-Derived Extracellular Vesicles in Bone-Related Diseases: Intercellular Communication Messengers and Therapeutic Engineering Protagonists.

Wang Y, Wen J, Lu T, Han W, Jiao K, Li H Int J Nanomedicine. 2024; 19:3233-3257.

PMID: 38601346 PMC: 11005933. DOI: 10.2147/IJN.S441467.

Bioprinting of gelatin-based materials for orthopedic application.

Waidi Y, Kariim I, Datta S Front Bioeng Biotechnol. 2024; 12:1357460.

PMID: 38544981 PMC: 10966130. DOI: 10.3389/fbioe.2024.1357460.

References

Okamoto K, Takayanagi H . Regulation of bone by the adaptive immune system in arthritis. Arthritis Res Ther. 2011; 13(3):219. PMC: 3218874. DOI: 10.1186/ar3323. View

Wang Z, Cohen K, Shao Y, Mole P, Dombkowski D, Scadden D . Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels. Blood. 2003; 103(1):100-9. DOI: 10.1182/blood-2003-04-1063. View

Hall K, Boumsell L, Schultze J, Boussiotis V, Dorfman D, Cardoso A . Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A. 1996; 93(21):11780-5. PMC: 38135. DOI: 10.1073/pnas.93.21.11780. View

Keller J, Catala-Lehnen P, Wintges K, Schulze J, Bickert T, Ito W . Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis. Biochem Biophys Res Commun. 2011; 417(1):217-22. DOI: 10.1016/j.bbrc.2011.11.088. View

Loots G, Kneissel M, Keller H, Baptist M, Chang J, Collette N . Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 2005; 15(7):928-35. PMC: 1172036. DOI: 10.1101/gr.3437105. View

Alexander K, Chang M, Maylin E, Kohler T, Muller R, Wu A . Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res. 2011; 26(7):1517-32. DOI: 10.1002/jbmr.354. View

Dacquin R, Domenget C, Kumanogoh A, Kikutani H, Jurdic P, Machuca-Gayet I . Control of bone resorption by semaphorin 4D is dependent on ovarian function. PLoS One. 2011; 6(10):e26627. PMC: 3202567. DOI: 10.1371/journal.pone.0026627. View

Varoga D, Drescher W, Pufe M, Groth G, Pufe T . Differential expression of vascular endothelial growth factor in glucocorticoid-related osteonecrosis of the femoral head. Clin Orthop Relat Res. 2009; 467(12):3273-82. PMC: 2772917. DOI: 10.1007/s11999-009-1076-3. View

Verborgt O, Gibson G, Schaffler M . Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. 2000; 15(1):60-7. DOI: 10.1359/jbmr.2000.15.1.60. View

10.

Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H . Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity. 2000; 13(5):621-31. DOI: 10.1016/s1074-7613(00)00062-5. View

11.

Crockett J, Rogers M, Coxon F, Hocking L, Helfrich M . Bone remodelling at a glance. J Cell Sci. 2011; 124(Pt 7):991-8. DOI: 10.1242/jcs.063032. View

12.

Chan B, Fuller E, Russell A, Smith S, Smith M, Jackson M . Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis Cartilage. 2011; 19(7):874-85. DOI: 10.1016/j.joca.2011.04.014. View

13.

Josefowicz S, Lu L, Rudensky A . Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30:531-64. PMC: 6066374. DOI: 10.1146/annurev.immunol.25.022106.141623. View

14.

Martin T, Sims N . Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med. 2005; 11(2):76-81. DOI: 10.1016/j.molmed.2004.12.004. View

15.

Silvestrini G, Ballanti P, Patacchioli F, Leopizzi M, Gualtieri N, Monnazzi P . Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat. J Mol Histol. 2005; 36(1-2):59-67. DOI: 10.1007/s10735-004-3839-1. View

16.

Xiong J, Onal M, Jilka R, Weinstein R, Manolagas S, OBrien C . Matrix-embedded cells control osteoclast formation. Nat Med. 2011; 17(10):1235-41. PMC: 3192296. DOI: 10.1038/nm.2448. View

17.

Zhao S, Zhang Y, Harris S, Ahuja S, Bonewald L . MLO-Y4 osteocyte-like cells support osteoclast formation and activation. J Bone Miner Res. 2002; 17(11):2068-79. DOI: 10.1359/jbmr.2002.17.11.2068. View

18.

NEUMAN W, NEUMAN M, Sammon P, CASARETT G . The metabolism of labeled parathyroid hormone. IV. Autoradiographic studies. Calcif Tissue Res. 1975; 18(4):263-70. DOI: 10.1007/BF02546245. View

19.

Tomkinson A, Reeve J, Shaw R, Noble B . The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab. 1997; 82(9):3128-35. DOI: 10.1210/jcem.82.9.4200. View

20.

Brunkow M, Gardner J, Van Ness J, Paeper B, Kovacevich B, Proll S . Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet. 2001; 68(3):577-89. PMC: 1274471. DOI: 10.1086/318811. View