Clinical Practice : Coeliac Disease

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2012 Mar 17

PMID 22422192

Citations 18

Authors

C M Frank Kneepkens

B Mary E von Blomberg

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Coeliac disease (CD) is an immune-mediated systemic condition elicited by gluten and related prolamines in genetically predisposed individuals and characterised by gluten-induced symptoms and signs, specific antibodies, a specific human leukocyte antigen (HLA) type and enteropathy. The risk of coeliac disease is increased in first-degree relatives, certain syndromes including Down syndrome and autoimmune disorders. It is thought to occur in 1 in 100-200 individuals, but still only one in four cases is diagnosed. Small-bowel biopsy is no longer deemed necessary in a subgroup of patients, i.e. when all of the following are present: typical symptoms or signs, high titres of and transglutaminase antibodies, endomysial antibodies, and HLA-type DQ2 or DQ8. In all other cases, small-bowel biopsy remains mandatory for a correct diagnosis. Therapy consists of a strictly gluten-free diet. This should result in complete disappearance of symptoms and of serological markers. Adequate follow-up is considered essential.

Conclusion: Although small-bowel biopsy may be omitted in a minority of patients, small-bowel biopsy is essential for a correct diagnosis of CD in all other cases. Diagnostic work-up should be completed before treatment with gluten-free diet instituted.

Citing Articles

Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies.

Ge H, Chen X World J Gastroenterol. 2024; 30(35):3932-3941.

PMID: 39351055 PMC: 11438662. DOI: 10.3748/wjg.v30.i35.3932.

Current knowledge and "myths" about celiac disease among physicians in the Republic of Kazakhstan: A countrywide cross-sectional study.

Kozhakhmetova A, Aidossov S, Kapassova A, Borsoldayeva K Front Public Health. 2022; 10:956135.

PMID: 36033766 PMC: 9411637. DOI: 10.3389/fpubh.2022.956135.

Acrodystrophic axonal polyneuropathy with celiac disease: a case report.

Bardakov S, Tran M, Lapin S, Moshnikova A, Kalinina E, Bogdanova E J Med Case Rep. 2021; 15(1):615.

PMID: 34920762 PMC: 8684204. DOI: 10.1186/s13256-021-03171-z.

Case Report: Papillary Thyroid Cancer in a Patient with Celiac Disease and Thalassemia Trait.

Albattah A, Imam Y, Saleh A, Ahmed K, Aboursheid T, Kohla S Case Rep Oncol. 2021; 13(3):1364-1367.

PMID: 33442356 PMC: 7772826. DOI: 10.1159/000511068.

The difference in symmetry of the enamel defects in celiac disease versus non-celiac pediatric population.

Macho V, de Barros Meneres Manso M, E Silva D, de Andrade D J Dent Sci. 2020; 15(3):345-350.

PMID: 32952893 PMC: 7486505. DOI: 10.1016/j.jds.2020.02.006.

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