The Cerebrospinal Fluid: Regulator of Neurogenesis, Behavior, and Beyond

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2012 Mar 15

PMID 22415326

Citations 75

Authors

Mauro W Zappaterra

Maria K Lehtinen

Affiliations

Soon will be listed here.

Abstract

The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances in proteomics research have enabled an improved characterization of the CSF from development through adulthood, and key neurogenic signaling pathways that are transmitted via the CSF are now being elucidated. Due to its immediate contact with neural stem cells in the developing and adult brain, the CSF's ability to swiftly distribute signals across vast distances in the central nervous system is opening avenues to novel and exciting therapeutic approaches. In this review, we will discuss the development of the choroid plexus-CSF system, and review the current literature on how the CSF actively regulates mammalian brain development, behavior, and responses to traumatic brain injury.

Citing Articles

Multimodal insights into adult neurogenesis: An integrative review of multi-omics approaches.

Li J, Huang L, Xiao W, Kong J, Hu M, Pan A Heliyon. 2025; 11(4):e42668.

PMID: 40051854 PMC: 11883395. DOI: 10.1016/j.heliyon.2025.e42668.

The influence of biomimetic conditions on neurogenic and neuroprotective properties of dedifferentiated fat cells.

Radoszkiewicz K, Rybkowska P, Szymanska M, Krzesniak N, Sarnowska A Stem Cells. 2024; 43(1).

PMID: 39576128 PMC: 11811640. DOI: 10.1093/stmcls/sxae066.

Radial glia progenitor polarity in health and disease.

Viola V, Chinnappa K, Francis F Front Cell Dev Biol. 2024; 12:1478283.

PMID: 39416687 PMC: 11479994. DOI: 10.3389/fcell.2024.1478283.

Neuropsychological complications of hypoprolactinemia.

Munro V, Wilkinson M, Imran S Rev Endocr Metab Disord. 2024; 25(6):1121-1126.

PMID: 38955985 DOI: 10.1007/s11154-024-09892-y.

The choroid plexus maintains adult brain ventricles and subventricular zone neuroblast pool, which facilitates poststroke neurogenesis.

Taranov A, Bedolla A, Iwasawa E, Brown F, Baumgartner S, Fugate E Proc Natl Acad Sci U S A. 2024; 121(28):e2400213121.

PMID: 38954546 PMC: 11252789. DOI: 10.1073/pnas.2400213121.

References

Reiter R, Tan D, Poeggeler B, Menendez-Pelaez A, Chen L, Saarela S . Melatonin as a free radical scavenger: implications for aging and age-related diseases. Ann N Y Acad Sci. 1994; 719:1-12. DOI: 10.1111/j.1749-6632.1994.tb56817.x. View

Craft S, Baker L, Montine T, Minoshima S, Watson G, Claxton A . Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2011; 69(1):29-38. PMC: 3260944. DOI: 10.1001/archneurol.2011.233. View

Schabitz W, Schwab S, Spranger M, Hacke W . Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1997; 17(5):500-6. DOI: 10.1097/00004647-199705000-00003. View

Schubert M, Brazil D, Burks D, Kushner J, Ye J, Flint C . Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci. 2003; 23(18):7084-92. PMC: 6740672. View

Lowery L, Sive H . Totally tubular: the mystery behind function and origin of the brain ventricular system. Bioessays. 2009; 31(4):446-58. PMC: 3003255. DOI: 10.1002/bies.200800207. View

McKelvie P, Rosen K, Kinney H . Insulin-like growth factor II expression in the developing human brain. J Neuropathol Exp Neurol. 1992; 51(4):464-71. DOI: 10.1097/00005072-199207000-00009. View

Sharma H, Johanson C . Intracerebroventricularly administered neurotrophins attenuate blood cerebrospinal fluid barrier breakdown and brain pathology following whole-body hyperthermia: an experimental study in the rat using biochemical and morphological approaches. Ann N Y Acad Sci. 2007; 1122:112-29. DOI: 10.1196/annals.1403.008. View

Awatramani R, Soriano P, Rodriguez C, Mai J, Dymecki S . Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003; 35(1):70-5. DOI: 10.1038/ng1228. View

Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin J, Yamada M, Spassky N . New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006; 311(5761):629-32. DOI: 10.1126/science.1119133. View

10.

Dugas J, Mandemakers W, Rogers M, Ibrahim A, Daneman R, Barres B . A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons. J Neurosci. 2008; 28(33):8294-305. PMC: 2567869. DOI: 10.1523/JNEUROSCI.2010-08.2008. View

11.

Mashayekhi F, Azari M, Moghadam L, Yazdankhah M, Naji M, Salehi Z . Changes in cerebrospinal fluid nerve growth factor levels during chick embryonic development. J Clin Neurosci. 2009; 16(10):1334-7. DOI: 10.1016/j.jocn.2009.03.023. View

12.

Sriram K, OCallaghan J . Divergent roles for tumor necrosis factor-alpha in the brain. J Neuroimmune Pharmacol. 2007; 2(2):140-53. DOI: 10.1007/s11481-007-9070-6. View

13.

Tan D, Manchester L, Sanchez-Barcelo E, Mediavilla M, Reiter R . Significance of high levels of endogenous melatonin in Mammalian cerebrospinal fluid and in the central nervous system. Curr Neuropharmacol. 2011; 8(3):162-7. PMC: 3001210. DOI: 10.2174/157015910792246182. View

14.

Chesik D, De Keyser J, Wilczak N . Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. Cytokine Growth Factor Rev. 2007; 18(3-4):267-78. DOI: 10.1016/j.cytogfr.2007.04.001. View

15.

Woollam D . The historical significance of the cerebrospinal fluid. Med Hist. 1957; 1(2):91-114. PMC: 1034258. DOI: 10.1017/s0025727300021025. View

16.

Chiaretti A, Antonelli A, Genovese O, Pezzotti P, Di Rocco C, Viola L . Nerve growth factor and doublecortin expression correlates with improved outcome in children with severe traumatic brain injury. J Trauma. 2008; 65(1):80-5. DOI: 10.1097/TA.0b013e31805f7036. View

17.

Kujuro Y, Suzuki N, Kondo T . Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc Natl Acad Sci U S A. 2010; 107(18):8259-64. PMC: 2889548. DOI: 10.1073/pnas.0911446107. View

18.

Borlongan C, Skinner S, Geaney M, Vasconcellos A, Elliott R, Emerich D . Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke. Stroke. 2004; 35(9):2206-10. DOI: 10.1161/01.STR.0000138954.25825.0b. View

19.

Liu W, Ye P, OKusky J, DErcole A . Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus. J Neurosci Res. 2009; 87(13):2821-32. DOI: 10.1002/jnr.22129. View

20.

Dauvilliers Y, Baumann C, Carlander B, Bischof M, Blatter T, Lecendreux M . CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. J Neurol Neurosurg Psychiatry. 2003; 74(12):1667-73. PMC: 1757412. DOI: 10.1136/jnnp.74.12.1667. View