Notch Signaling in Diabetic Nephropathy

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2012 Mar 15

PMID 22414874

Citations 36

Authors

Ramon Bonegio

Katalin Susztak

Affiliations

Soon will be listed here.

Abstract

Notch signaling is an evolutionarily conserved cell-cell signaling system that controls the fate of cells during development. In this review, we will summarize the literature that notch signaling during development controls nephron number and segmentation and therefore could influence kidney disease susceptibility. We will also review the evidence that Notch is reactivated in adult-onset diabetic kidney disease where it promotes the development of nephropathy including glomerulopathy, tubulointerstitial fibrosis and possibly arteriopathy and inflammation. Finally, we will review the evidence that blockade of pathogenic Notch signaling alters the natural history of diabetic nephropathy and thus could represent a novel therapeutic approach to the management of diabetic kidney disease.

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