Inter-individual Variability in the Pre-clinical Drug Cardiotoxic Safety Assessment--analysis of the Age-cardiomyocytes Electric Capacitance Dependence

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2012 Mar 14

PMID 22411323

Citations 19

Authors

Sebastian Polak

Kamil Fijorek

Affiliations

Soon will be listed here.

Abstract

Electrical phenomena located within the plasma membrane of the mammalian cardiac cells are connected with the cells' main physiological functions--signals processing and contractility. They were extensively studied and described mathematically in so-called Hodgkin-Huxley paradigm. One of the physiological parameters, namely cell electric capacitance, has not been analyzed in-depth. The aim of the study was to validate the mechanistic model describing the capacitive properties of cells, based on a collected experimental dataset which describes the electric capacitance of human ventricular myocytes. The gathered data was further utilized for developing an empirical correlation between a healthy individual's age and cardiomyocyte electric capacitance.

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