10-Shogaol, an Antioxidant from Zingiber Officinale for Skin Cell Proliferation and Migration Enhancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2012 Mar 13

PMID 22408422

Citations 19

Authors

Chung-Yi Chen

Kuo-Chen Cheng

Andy Y Chang

Ying-Ting Lin

You-Cheng Hseu

Hui-Min Wang

Affiliations

Soon will be listed here.

Abstract

In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.

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References

Stavri G, Hong Y, Zachary I, Breier G, Baskerville P, Yla-Herttuala S . Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells. FEBS Lett. 1995; 358(3):311-5. DOI: 10.1016/0014-5793(94)01458-d. View

Chen C, Tai C, Cheng J, Zheng J, Chen Y, Liu T . 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010; 58(9):5604-11. DOI: 10.1021/jf904260b. View

Gan F, Nagle A, Ang X, Ho O, Tan S, Yang H . Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. Apoptosis. 2011; 16(8):856-67. DOI: 10.1007/s10495-011-0611-3. View

Gerber H, Dixit V, Ferrara N . Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem. 1998; 273(21):13313-6. DOI: 10.1074/jbc.273.21.13313. View

Mladenovic M, Mihailovic M, Bogojevic D, Matic S, Niciforovic N, Mihailovic V . In vitro antioxidant activity of selected 4-hydroxy-chromene-2-one derivatives-SAR, QSAR and DFT studies. Int J Mol Sci. 2011; 12(5):2822-41. PMC: 3116159. DOI: 10.3390/ijms12052822. View

Geback T, Schulz M, Koumoutsakos P, Detmar M . TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques. 2009; 46(4):265-74. DOI: 10.2144/000113083. View

Bhagavathula N, Warner R, DaSilva M, McClintock S, Barron A, Aslam M . A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin. Wound Repair Regen. 2009; 17(3):360-6. PMC: 2819156. DOI: 10.1111/j.1524-475X.2009.00483.x. View

Rolfe K, Richardson J, Vigor C, Irvine L, Grobbelaar A, Linge C . A role for TGF-beta1-induced cellular responses during wound healing of the non-scarring early human fetus?. J Invest Dermatol. 2007; 127(11):2656-67. DOI: 10.1038/sj.jid.5700951. View

Amjad S, Carachi R, Edward M . Keratinocyte regulation of TGF-beta and connective tissue growth factor expression: a role in suppression of scar tissue formation. Wound Repair Regen. 2007; 15(5):748-55. DOI: 10.1111/j.1524-475X.2007.00281.x. View

10.

Chen B, Chang H, Huang H, Chong I, Chen J, Chen C . (-)-Anonaine induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. J Agric Food Chem. 2011; 59(6):2284-90. DOI: 10.1021/jf103488j. View

11.

Afzal M, Menon M, Pesek J, Dhami M . Ginger: an ethnomedical, chemical and pharmacological review. Drug Metabol Drug Interact. 2002; 18(3-4):159-90. DOI: 10.1515/dmdi.2001.18.3-4.159. View

12.

Shao X, Lv L, Parks T, Wu H, Ho C, Sang S . Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. J Agric Food Chem. 2010; 58(24):12608-14. PMC: 3446752. DOI: 10.1021/jf1029256. View

13.

Wang H, Chen C, Wen Z . Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase. Exp Dermatol. 2010; 20(3):242-8. DOI: 10.1111/j.1600-0625.2010.01161.x. View

14.

Shoji N, Iwasa A, Takemoto T, Ishida Y, Ohizumi Y . Cardiotonic principles of ginger (Zingiber officinale Roscoe). J Pharm Sci. 1982; 71(10):1174-5. DOI: 10.1002/jps.2600711025. View

15.

Trompezinski S, Berthier-Vergnes O, Denis A, Schmitt D, Viac J . Comparative expression of vascular endothelial growth factor family members, VEGF-B, -C and -D, by normal human keratinocytes and fibroblasts. Exp Dermatol. 2004; 13(2):98-105. DOI: 10.1111/j.0906-6705.2004.00137.x. View

16.

Waddington R, Alraies A, Colombo J, Sloan A, Okazaki J, Moseley R . Characterization of oxidative stress status during diabetic bone healing. Cells Tissues Organs. 2011; 194(2-4):307-12. DOI: 10.1159/000324251. View

17.

Riedel K, Riedel F, Goessler U, Germann G, Sauerbier M . Tgf-beta antisense therapy increases angiogenic potential in human keratinocytes in vitro. Arch Med Res. 2006; 38(1):45-51. DOI: 10.1016/j.arcmed.2006.04.010. View

18.

Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y . A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1. Nutr Neurosci. 2006; 9(3-4):169-78. DOI: 10.1080/110284150600955164. View

19.

Panchatcharam M, Miriyala S, Gayathri V, Suguna L . Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. 2006; 290(1-2):87-96. DOI: 10.1007/s11010-006-9170-2. View

20.

Wang H, Chen C, Chen H, Huang W, Lin W, Chen T . Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii. Phytother Res. 2010; 24(12):1825-30. DOI: 10.1002/ptr.3201. View