Integrated Control of Axonemal Dynein AAA(+) Motors

Overview

Journal J Struct Biol

Specialties Cell Biology
Molecular Biology

Date 2012 Mar 13

PMID 22406539

Citations 20

Authors

Stephen M King

Affiliations

Soon will be listed here.

Abstract

Axonemal dyneins are AAA(+) enzymes that convert ATP hydrolysis to mechanical work. This leads to the sliding of doublet microtubules with respect to each other and ultimately the generation of ciliary/flagellar beating. However, in order for useful work to be generated, the action of individual dynein motors must be precisely controlled. In addition, cells modulate the motility of these organelles through a variety of second messenger systems and these signals too must be integrated by the dynein motors to yield an appropriate output. This review describes the current status of efforts to understand dynein control mechanisms and their connectivity focusing mainly on studies of the outer dynein arm from axonemes of the unicellular biflagellate green alga Chlamydomonas.

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