Epidemiology of Classic and AIDS-related Kaposi's Sarcoma in the USA: Incidence, Survival, and Geographical Distribution from 1975 to 2005

Overview

Journal Epidemiol Infect

Publisher Cambridge University Press

Specialties Infectious Diseases
Public Health

Date 2012 Mar 13

PMID 22404880

Citations 12

Authors

A W Armstrong

K H Lam

E P Chase

Affiliations

Soon will be listed here.

Abstract

This study aimed to examine trends in incidence, geographical distribution, and survival of classic and AIDS-related Kaposi's sarcoma (KS) in the general US population using Surveillance, Epidemiology, and End Results (SEER) tumour registries with 12 066 patients diagnosed with KS between 1975 and 2005. Although the age-adjusted standardized incidence ratio (SIR) of AIDS-related KS (1·9) during 1980-2005 was not significantly higher than that of classic KS (1·4) during 1975-2005 (P = 0·78), the trends in annual SIR rates revealed distinct patterns. While the SIR for AIDS-related KS declined across all registries from the early 1990s (4·6) to late-1990s (0·3) (P = 0·05), the SIR of classic KS remained relatively steady (1·7). In both forms the SIR of KS was highest in metropolitan areas. The 5-year survival rates for patients with AIDS-related KS improved from 12·1% (1980-1995) to 54% (1996-2005) (P = 0·05). Survival rates for patients with classic KS remained stable, ranging from 75·7% to 88·6% during the 30-year period. These results may reflect improved HIV treatment.

Citing Articles

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References

Mocroft A, Kirk O, Clumeck N, Gargalianos-Kakolyris P, Trocha H, Chentsova N . The changing pattern of Kaposi sarcoma in patients with HIV, 1994-2003: the EuroSIDA Study. Cancer. 2004; 100(12):2644-54. DOI: 10.1002/cncr.20309. View

Greenblatt R, Jacobson L, Levine A, Melnick S, Anastos K, Cohen M . Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women. J Infect Dis. 2001; 183(7):1130-4. DOI: 10.1086/319270. View

Engels E, Pfeiffer R, Goedert J, Virgo P, McNeel T, Scoppa S . Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS. 2006; 20(12):1645-54. DOI: 10.1097/01.aids.0000238411.75324.59. View

Osmond D, Buchbinder S, Cheng A, Graves A, Vittinghoff E, Cossen C . Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. JAMA. 2002; 287(2):221-5. DOI: 10.1001/jama.287.2.221. View

Jaffe H, Bregman D, Selik R . Acquired immune deficiency syndrome in the United States: the first 1,000 cases. J Infect Dis. 1983; 148(2):339-45. DOI: 10.1093/infdis/148.2.339. View

Shiels M . Errors in a study of proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007. JAMA. 2011; 306(14):1548. PMC: 4896214. DOI: 10.1001/jama.2011.1467. View

Melbye M, Cook P, Hjalgrim H, Begtrup K, Simpson G, Biggar R . Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Int J Cancer. 1998; 77(4):543-8. DOI: 10.1002/(sici)1097-0215(19980812)77:4<543::aid-ijc12>3.0.co;2-7. View

Beral V . Epidemiology of Kaposi's sarcoma. Cancer Surv. 1991; 10:5-22. View

Shiels M, Pfeiffer R, Hall H, Li J, Goedert J, Morton L . Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007. JAMA. 2011; 305(14):1450-9. PMC: 3909038. DOI: 10.1001/jama.2011.396. View

10.

Biggar R, Curtis R, Cote T, Rabkin C, Melbye M . Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome. Am J Epidemiol. 1994; 139(4):362-8. DOI: 10.1093/oxfordjournals.aje.a117008. View

11.

Di Lorenzo G . Update on classic Kaposi sarcoma therapy: new look at an old disease. Crit Rev Oncol Hematol. 2008; 68(3):242-9. DOI: 10.1016/j.critrevonc.2008.06.007. View

12.

Eltom M, Jemal A, Mbulaiteye S, Devesa S, Biggar R . Trends in Kaposi's sarcoma and non-Hodgkin's lymphoma incidence in the United States from 1973 through 1998. J Natl Cancer Inst. 2002; 94(16):1204-10. DOI: 10.1093/jnci/94.16.1204. View

13.

Jacobson L, Yamashita T, Detels R, Margolick J, Chmiel J, Kingsley L . Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr. 1999; 21 Suppl 1:S34-41. View

14.

Laor Y, Schwartz R . Epidemiologic aspects of american Kaposi's sarcoma. J Surg Oncol. 1979; 12(4):299-303. DOI: 10.1002/jso.2930120403. View

15.

Biggar R, Horm J, Fraumeni Jr J, Greene M, Goedert J . Incidence of Kaposi's sarcoma and mycosis fungoides in the United States including Puerto Rico, 1973-81. J Natl Cancer Inst. 1984; 73(1):89-94. View

16.

Mesri E, Cesarman E, Boshoff C . Kaposi's sarcoma and its associated herpesvirus. Nat Rev Cancer. 2010; 10(10):707-19. PMC: 4721662. DOI: 10.1038/nrc2888. View

17.

Biggar R . AIDS-related cancers in the era of highly active antiretroviral therapy. Oncology (Williston Park). 2001; 15(4):439-48; discussion 448-9. View

18.

Gazouli M, Papaconstantinou I, Zavos G, Metaxa-Mariatou V, Nasioulas G, Boletis J . Human herpesvirus type 8 genotypes in iatrogenic, classic and AIDS-associated Kaposi's sarcoma from Greece. Anticancer Res. 2004; 24(3a):1597-602. View

19.

Rosenberg P, Biggar R . Trends in HIV incidence among young adults in the United States. JAMA. 1998; 279(23):1894-9. DOI: 10.1001/jama.279.23.1894. View

20.

Dal Maso L, Polesel J, Ascoli V, Zambon P, Budroni M, Ferretti S . Classic Kaposi's sarcoma in Italy, 1985-1998. Br J Cancer. 2004; 92(1):188-93. PMC: 2361748. DOI: 10.1038/sj.bjc.6602265. View