Oxidative Stress in Patients with Primary Insomnia

Overview

Journal Prog Neuropsychopharmacol Biol Psychiatry

Specialty Psychiatry

Date 2012 Mar 10

PMID 22401887

Citations 43

Authors

Mustafa Gulec

Halil Ozkol

Yavuz Selvi

Yasin Tuluce

Adem Aydin

Lutfullah Besiroglu

Pinar Guzel Ozdemir

Affiliations

Soon will be listed here.

Abstract

Objective: Many physiological and pathological processes, such as infections, environmental toxins, and ionizing radiation increase bodily concentrations of oxidizing substances, known as free radicals, which lead to neurodegenerative disorders. Sleep is one of the most important factors contributing to health; however, insomnia is among the most prevalent health complaints.

Methods: In this study, for the first time in the literature, we investigated the effects of primary insomnia on certain oxidative stress biomarkers. For this purpose, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities and levels of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in 30 patients with primary insomnia and 30 healthy volunteers

Results: Our results show that the patients with primary insomnia had significantly lower GSH-Px activity and higher MDA levels compared with the controls.

Conclusion: These results may indicate the important role of sleep in attenuating oxidative stress.

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