Collagen VI Encodes Antimicrobial Activity: Novel Innate Host Defense Properties of the Extracellular Matrix

Overview

Journal J Innate Immun

Publisher Karger

Specialty Allergy & Immunology

Date 2012 Mar 9

PMID 22398575

Citations 11

Authors

Suado M Abdillahi

Selma Balvanovic

Maria Baumgarten

Matthias Morgelin

Affiliations

Soon will be listed here.

Abstract

Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.

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