» Articles » PMID: 22396861

Old Age As a Privilege of the "selfish Ones"

Overview
Journal Aging Dis
Specialty Geriatrics
Date 2012 Mar 8
PMID 22396861
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

In the past couple of centuries, scientists proposed great number of aging theories but neither of them appears to be fully satisfactory. In the statistical sense, we are dealing with an even greater challenge because large array of factors affects the aging process. Although at this point the most of these factors are well known, it is the very fact of their innumerability that complicates approaches to the issue at hand. Both in life and in medicine, the cause behind an effect can rarely be unequivocally determined. Thus, it appears that through out human history longevity has been primarily affected by eradication of diseases, especially by eradication of infectious diseases and introduction of the vaccines. For that reason, maybe we should not be referring to this issue as the «fountain of youth» but rather as the «vaccine of youth». The postulate that genetic instability is the precipitating factor both of aging and cancer has withstood many tests and keeps on being reaffirmed. For this reason, it is legitimate to pose a question of whether long-lived individuals may be those with «selfish» genes and more stable genetic material. They certainly cannot avoid aging, but aging in such individuals could be delayed due to steady character of their genome, which is less susceptible to mutations. On the population level, they constitute minority because stable genome would represent an obstacle to successful evolution of the species. If this was not the case, we might not be writing all these texts today.

Citing Articles

Molecular hallmarks of ageing in amyotrophic lateral sclerosis.

Jagaraj C, Shadfar S, Kashani S, Saravanabavan S, Farzana F, Atkin J Cell Mol Life Sci. 2024; 81(1):111.

PMID: 38430277 PMC: 10908642. DOI: 10.1007/s00018-024-05164-9.


Understanding cellular senescence: pathways involved, therapeutics and longevity aiding.

Kumar A, Thirumurugan K Cell Cycle. 2023; 22(20):2324-2345.

PMID: 38031713 PMC: 10730163. DOI: 10.1080/15384101.2023.2287929.


A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of aging.

Yu W, Gargett T, Du Z Aging (Albany NY). 2023; 15(17):8537-8551.

PMID: 37659107 PMC: 10522393. DOI: 10.18632/aging.205016.


Metabolic Rewiring by Human Placenta-Derived Mesenchymal Stem Cell Therapy Promotes Rejuvenation in Aged Female Rats.

Kim K, Lee K Int J Mol Sci. 2022; 23(1).

PMID: 35008991 PMC: 8745533. DOI: 10.3390/ijms23010566.


The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth.

Al-Samerria S, Radovick S Cells. 2021; 10(10).

PMID: 34685644 PMC: 8534318. DOI: 10.3390/cells10102664.


References
1.
Erceg P, Milosevic D, Despotovic N, Davidovic M . Chromosomal changes in ageing. J Genet. 2008; 86(3):277-8. DOI: 10.1007/s12041-007-0035-6. View

2.
Bulckaen H, Prevost G, Boulanger E, Robitaille G, Roquet V, Gaxatte C . Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging. Am J Physiol Heart Circ Physiol. 2008; 294(4):H1562-70. DOI: 10.1152/ajpheart.00241.2007. View

3.
Christensen K, McGue M, Petersen I, Jeune B, Vaupel J . Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci U S A. 2008; 105(36):13274-9. PMC: 2517602. DOI: 10.1073/pnas.0804931105. View

4.
Despotovic N, Erceg P, Potic B, Stojanovic J, Milosevic D, Davidovic M . Biogerontology in Serbia. Biogerontology. 2010; 12(1):11-5. DOI: 10.1007/s10522-010-9275-6. View

5.
Davidovic M, Erceg P, Trailov D, Djurica S, Milosevic D, Stevic R . The privilege to be old. Gerontology. 2003; 49(5):335-9. DOI: 10.1159/000071716. View