The Effect of Neoadjuvant Chemoradiotherapy on Airway Colonization and Postoperative Respiratory Complications in Patients Undergoing Oesophagectomy for Oesophageal Cancer

Overview

Journal Interact Cardiovasc Thorac Surg

Publisher Oxford University Press

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2012 Mar 7

PMID 22392934

Citations 6

Authors

Reza Bagheri

Mohammad Taghi RajabiMashhadi

Kiyarash Ghazvini

Amir Asnaashari

Ali Zahediyan

Mehdi Abasi Sahebi

Affiliations

Soon will be listed here.

Abstract

Respiratory complication is one of the important postoperative complications of oesophageal cancer. The aim of this study was to evaluate whether neoadjuvant chemotherapy before surgery is effective for postoperative respiratory complications. In this study, patients with oesophageal cancer were divided into two group: one with neoadjuvant therapy and the other without neoadjuvant therapy. Before surgery, they all underwent bronchoscopy and bronchoalveolar lavage. We evaluated respiratory complications and the effects of preoperative neoadjuvant therapy. Forty patients (M/F = 23/17 and mean age 61 years) were enrolled in this study. Twenty-two cases had cancer in the middle part and 18 in the lower part of the oesophagus. Significant correlation was observed between the number of positive micro-organism and difficulty in weaning and receiving neoadjuvant therapy. But no significant correlation was found between neoadjuvant therapy and respiratory complications.

Citing Articles

Analyzing the impact of neoadjuvant radiation dose on pathologic response and survival outcomes in esophageal and gastroesophageal cancers.

Li R, Shinde A, Glaser S, Chao J, Kim J, Karam S J Gastrointest Oncol. 2019; 10(4):712-722.

PMID: 31392052 PMC: 6657311. DOI: 10.21037/jgo.2019.02.18.

Reliability and safety of minimally invasive esophagectomy after neoadjuvant chemoradiation: a retrospective study.

Liu G, Han Y, Peng L, Wang K, Fan Y J Cardiothorac Surg. 2019; 14(1):97.

PMID: 31138245 PMC: 6537410. DOI: 10.1186/s13019-019-0920-0.

Society for Translational Medicine Expert Consensus on the prevention and treatment of postoperative pulmonary infection in esophageal cancer patients.

Yu Z, Li S, Liu D, Liu L, He J, Huang Y J Thorac Dis. 2018; 10(2):1050-1057.

PMID: 29607180 PMC: 5864615. DOI: 10.21037/jtd.2018.01.34.

Using the Comprehensive Complication Index to Assess the Impact of Neoadjuvant Chemoradiotherapy on Complication Severity After Esophagectomy for Cancer.

Nederlof N, Slaman A, van Hagen P, van der Gaast A, Slankamenac K, Gisbertz S Ann Surg Oncol. 2016; 23(12):3964-3971.

PMID: 27301849 PMC: 5047940. DOI: 10.1245/s10434-016-5291-3.

The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery.

Rajabi Mashhadi M, Bagheri R, Abdollahi A, Ghamari M, Shahidsales S, Salehi M Iran J Otorhinolaryngol. 2016; 27(81):279-84.

PMID: 26788476 PMC: 4710880.

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