Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

Overview

Journal Curr Proteomics

Publisher Bentham Science Publishers

Date 2012 Mar 6

PMID 22389641

Citations 11

Authors

Wen Zhou

Kristina Hakansson

Affiliations

Soon will be listed here.

Abstract

Fourier transform tandem mass spectrometry (MS/MS) provides high mass accuracy, high sensitivity, and analytical versatility and has therefore emerged as an indispensable tool for structural elucidation of biomolecules. Glycosylation is one of the most common posttranslational modifications, occurring in ~50% of proteins. However, due to the structural diversity of carbohydrates, arising from non-template driven biosynthesis, achievement of detailed structural insight is highly challenging. This review briefly discusses carbohydrate sample preparation and ionization methods, and highlights recent developments in alternative high-resolution MS/MS strategies, including infrared multiphoton dissociation (IRMPD), electron capture dissociation (ECD), and electron detachment dissociation (EDD), for carbohydrates with a focus on glycans and proteoglycans from mammalian glycoproteins.

Citing Articles

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