Simulation of Lower Limb Axial Arterial Length Change During Locomotion

Overview

Journal J Biomech

Specialty Physiology

Date 2012 Mar 6

PMID 22386106

Citations 4

Authors

Melissa D Young

Matthew C Streicher

Richard J Beck

Antonie J van den Bogert

Azita Tajaddini

Brian L Davis

Affiliations

Soon will be listed here.

Abstract

The effect of external forces on axial arterial wall mechanics has conventionally been regarded as secondary to hemodynamic influences. However, arteries are similar to muscles in terms of the manner in which they traverse joints, and their three-dimensional geometrical requirements for joint motion. This study considers axial arterial shortening and elongation due to motion of the lower extremity during gait, ascending stairs, and sitting-to-standing motion. Arterial length change was simulated by means of a graphics based anatomic and kinematic model of the lower extremity. This model estimated the axial shortening to be as much as 23% for the femoropopliteal arterial region and as much as 21% for the iliac artery. A strong correlation was observed between femoropopliteal artery shortening and maximum knee flexion angle (r²=0.8) as well as iliac artery shortening and maximum hip angle flexion (r²=0.9). This implies a significant mechanical influence of locomotion on arterial behavior in addition to hemodynamics factors. Vascular tissue has high demands for axial compliance that should be considered in the pathology of atherosclerosis and the design of vascular implants.

Citing Articles

Outcomes of Self-Expanding Covered Stents for the Treatment of External ILIAC Artery Obstructive Disease.

Squizzato F, Mosquera-Rey V, Zanabili Al-Sibbai A, Camblor Santervas L, Pasqui E, Palasciano G Cardiovasc Intervent Radiol. 2023; 46(5):579-587.

PMID: 36826489 PMC: 10156894. DOI: 10.1007/s00270-023-03370-9.

Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons.

Goel E, Erwin M, Cawthon C, Schaff C, Fedor N, Rayl T Molecules. 2020; 25(7).

PMID: 32244375 PMC: 7180741. DOI: 10.3390/molecules25071596.

Impact of Chronic Renal Failure on Safety and Effectiveness of Paclitaxel-Eluting Stents for Femoropopliteal Artery Disease: Subgroup Analysis from Zilver PTX Post-Market Surveillance Study in Japan.

Ogawa Y, Yokoi H, Ohki T, Kichikawa K, Nakamura M, Komori K Cardiovasc Intervent Radiol. 2017; 40(11):1669-1677.

PMID: 28488101 PMC: 5651711. DOI: 10.1007/s00270-017-1673-6.

Variables decreasing tip movement of peripherally inserted central catheters in pediatric patients.

Gnannt R, Connolly B, Parra D, Amaral J, Moineddin R, Thakor A Pediatr Radiol. 2016; 46(11):1532-8.

PMID: 27272928 DOI: 10.1007/s00247-016-3648-1.

References

Delp S, Anderson F, Arnold A, Loan P, Habib A, John C . OpenSim: open-source software to create and analyze dynamic simulations of movement. IEEE Trans Biomed Eng. 2007; 54(11):1940-50. DOI: 10.1109/TBME.2007.901024. View

Ballyk P, Walsh C, Butany J, Ojha M . Compliance mismatch may promote graft-artery intimal hyperplasia by altering suture-line stresses. J Biomech. 1998; 31(3):229-37. DOI: 10.1016/s0197-3975(97)00111-5. View

Stagni R, Fantozzi S, Cappello A, Leardini A . Quantification of soft tissue artefact in motion analysis by combining 3D fluoroscopy and stereophotogrammetry: a study on two subjects. Clin Biomech (Bristol). 2005; 20(3):320-9. DOI: 10.1016/j.clinbiomech.2004.11.012. View

Cheng C, Choi G, Herfkens R, Taylor C . The effect of aging on deformations of the superficial femoral artery resulting from hip and knee flexion: potential clinical implications. J Vasc Interv Radiol. 2009; 21(2):195-202. PMC: 2818320. DOI: 10.1016/j.jvir.2009.08.027. View

Gleason R, Gray S, Wilson E, Humphrey J . A multiaxial computer-controlled organ culture and biomechanical device for mouse carotid arteries. J Biomech Eng. 2005; 126(6):787-95. DOI: 10.1115/1.1824130. View

Choi G, Cheng C, Wilson N, Taylor C . Methods for quantifying three-dimensional deformation of arteries due to pulsatile and nonpulsatile forces: implications for the design of stents and stent grafts. Ann Biomed Eng. 2008; 37(1):14-33. DOI: 10.1007/s10439-008-9590-0. View

Scheinert D, Scheinert S, Sax J, Piorkowski C, Braunlich S, Ulrich M . Prevalence and clinical impact of stent fractures after femoropopliteal stenting. J Am Coll Cardiol. 2005; 45(2):312-5. DOI: 10.1016/j.jacc.2004.11.026. View

Delp S, Loan J . A graphics-based software system to develop and analyze models of musculoskeletal structures. Comput Biol Med. 1995; 25(1):21-34. DOI: 10.1016/0010-4825(95)98882-e. View

Wensing P, Scholten F, Buijs P, Hartkamp M, Mali W, Hillen B . Arterial tortuosity in the femoropopliteal region during knee flexion: a magnetic resonance angiographic study. J Anat. 1995; 187 ( Pt 1):133-9. PMC: 1167356. View

10.

Giannattasio C, Failla M, Emanuelli G, Grappiolo A, BOFFI L, Corsi D . Local effects of atherosclerotic plaque on arterial distensibility. Hypertension. 2001; 38(5):1177-80. DOI: 10.1161/hy1101.095994. View

11.

Mironov V, Kasyanov V, McAllister K, Oliver S, Sistino J, Markwald R . Perfusion bioreactor for vascular tissue engineering with capacities for longitudinal stretch. J Craniofac Surg. 2003; 14(3):340-7. DOI: 10.1097/00001665-200305000-00012. View

12.

Iida O, Nanto S, Uematsu M, Morozumi T, Kotani J, Awata M . Effect of exercise on frequency of stent fracture in the superficial femoral artery. Am J Cardiol. 2006; 98(2):272-4. DOI: 10.1016/j.amjcard.2006.01.091. View

13.

BROWSE N, Young A, Thomas M . The effect of bending on canine and human arterial walls and on blood flow. Circ Res. 1979; 45(1):41-7. DOI: 10.1161/01.res.45.1.41. View

14.

Vernon P, Delattre J, Johnson E, Palot J, Clement C . Dynamic modifications of the popliteal arterial axis in the sagittal plane during flexion of the knee. Surg Radiol Anat. 1987; 9(1):37-41. DOI: 10.1007/BF02116852. View

15.

Andriacchi T, Alexander E . Studies of human locomotion: past, present and future. J Biomech. 2000; 33(10):1217-24. DOI: 10.1016/s0021-9290(00)00061-0. View

16.

Criqui M . Peripheral arterial disease--epidemiological aspects. Vasc Med. 2002; 6(3 Suppl):3-7. DOI: 10.1177/1358836X0100600i102. View

17.

Cheng C, Wilson N, Hallett R, Herfkens R, Taylor C . In vivo MR angiographic quantification of axial and twisting deformations of the superficial femoral artery resulting from maximum hip and knee flexion. J Vasc Interv Radiol. 2006; 17(6):979-87. DOI: 10.1097/01.RVI.0000220367.62137.e8. View

18.

Choi G, Shin L, Taylor C, Cheng C . In vivo deformation of the human abdominal aorta and common iliac arteries with hip and knee flexion: implications for the design of stent-grafts. J Endovasc Ther. 2009; 16(5):531-8. PMC: 2793421. DOI: 10.1583/09-2806.1. View

19.

Seliktar D, Nerem R, Galis Z . Mechanical strain-stimulated remodeling of tissue-engineered blood vessel constructs. Tissue Eng. 2003; 9(4):657-66. DOI: 10.1089/107632703768247359. View