Bioinspired Organocatalytic Asymmetric Reactions

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2012 Mar 2

PMID 22378196

Citations 12

Authors

Luca Bernardi

Mariafrancesca Fochi

Mauro Comes Franchini

Alfredo Ricci

Affiliations

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Abstract

Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.

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