Multiple Modes of Cytoplasmic Dynein Regulation

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2012 Mar 1

PMID 22373868

Citations 99

Authors

Richard B Vallee

Richard J McKenney

Kassandra M Ori-McKenney

Affiliations

Soon will be listed here.

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

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