A Dual Cytotoxic and Anti-angiogenic Water-soluble Gold(III) Complex Induces Endoplasmic Reticulum Damage in HeLa Cells

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2012 Mar 1

PMID 22373586

Citations 9

Authors

Jing-Jing Zhang

Raymond Wai-Yin Sun

Chi-Ming Che

Affiliations

Soon will be listed here.

Abstract

The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.

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