The Prostate Cancer Bone Marrow Niche: More Than Just 'fertile Soil'

Overview

Journal Asian J Androl

Specialty Urology

Date 2012 Feb 28

PMID 22367179

Citations 30

Authors

Elisabeth A Pedersen

Yusuke Shiozawa

Kenneth J Pienta

Russell S Taichman

Affiliations

Soon will be listed here.

Abstract

The hematopoietic stem cell (HSC) niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer (PCa) has only been recently considered to be a specialized 'niche' as well. New evidence supports the fact that disseminated tumor cells (DTCs) of PCa actually target the HSC niche, displace the occupant HSCs and take up residence in the pre-existing niche space. This review describes some of the evidence and mechanisms by which DTCs act as molecular parasites of the HSC niche. Furthermore, the interactions between DTCs, HSCs and the niche may provide new targets for niche-directed therapy, as well as insight into the perplexing clinical manifestations of metastatic PCa disease.

Citing Articles

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Conte M, Tomaciello M, De Feo M, Frantellizzi V, Marampon F, De Cristofaro F Biomedicines. 2025; 13(2).

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Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment.

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Patient-Derived Conditionally Reprogrammed Cells in Prostate Cancer Research.

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