Effect of Different Doses of Aerobic Exercise on Total White Blood Cell (WBC) and WBC Subfraction Number in Postmenopausal Women: Results from DREW

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Feb 25

PMID 22363616

Citations 40

Authors

Neil M Johannsen

Damon L Swift

William D Johnson

Vishwa D Dixit

Conrad P Earnest

Steven N Blair

Timothy S Church

Affiliations

Soon will be listed here.

Abstract

Background: Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts.

Purpose: To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin.

Methods: Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg(-1)⋅week(-1) (KKW) for 6 months at an intensity of 50% VO2peak.

Results: A dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (-163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (-152.6±115.1 cells/µL) compared with both the control and 4KKW groups (96.4±119.0 and 21.9±95.3 cells/µL, respectively) and in the 8KKW group (-102.4±125.0 cells/µL) compared with the control. When divided into high/low baseline WBC categories (median split), a dose-dependent decrease in both total WBCs (P = 0.003) and neutrophils (P<0.001) was observed in women with high baseline WBC counts. The effects of exercise dose on total WBC and neutrophil counts persisted after accounting for significant independent effects of change in waist circumference and IL-6.

Conclusion: Aerobic exercise training reduces total WBC and neutrophil counts, in a dose-dependent manner, in overweight/obese postmenopausal women and is especially beneficial for those with systemic low grade inflammation.

Clinical Trials Identifier: NCT00011193.

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References

Morss G, Jordan A, Skinner J, Dunn A, Church T, Earnest C . Dose Response to Exercise in Women aged 45-75 yr (DREW): design and rationale. Med Sci Sports Exerc. 2004; 36(2):336-44. DOI: 10.1249/01.MSS.0000113738.06267.E5. View

Angeli F, Angeli E, Ambrosio G, Mazzotta G, Reboldi G, Verdecchia P . Neutrophil count for the identification of postmenopausal hypertensive women at increased cardiovascular risk. Obstet Gynecol. 2010; 115(4):695-703. DOI: 10.1097/AOG.0b013e3181d53df6. View

Dixit V, Schaffer E, Pyle R, Collins G, Sakthivel S, Palaniappan R . Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest. 2004; 114(1):57-66. PMC: 437970. DOI: 10.1172/JCI21134. View

Church T, Earnest C, Skinner J, Blair S . Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA. 2007; 297(19):2081-91. DOI: 10.1001/jama.297.19.2081. View

Gillum R, Ingram D, Makuc D . White blood cell count, coronary heart disease, and death: the NHANES I Epidemiologic Follow-up Study. Am Heart J. 1993; 125(3):855-63. DOI: 10.1016/0002-8703(93)90181-8. View

Pratley R, Wilson C, Bogardus C . Relation of the white blood cell count to obesity and insulin resistance: effect of race and gender. Obes Res. 1995; 3(6):563-71. DOI: 10.1002/j.1550-8528.1995.tb00191.x. View

Vozarova B, Weyer C, Lindsay R, Pratley R, Bogardus C, Tataranni P . High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002; 51(2):455-61. DOI: 10.2337/diabetes.51.2.455. View

Rana J, Boekholdt S, Ridker P, Jukema J, Luben R, Bingham S . Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study. J Intern Med. 2007; 262(6):678-89. DOI: 10.1111/j.1365-2796.2007.01864.x. View

Zarkesh-Esfahani H, Pockley A, Wu Z, Hellewell P, Weetman A, Ross R . Leptin indirectly activates human neutrophils via induction of TNF-alpha. J Immunol. 2004; 172(3):1809-14. DOI: 10.4049/jimmunol.172.3.1809. View

10.

Claycombe K, King L, Fraker P . A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc Natl Acad Sci U S A. 2008; 105(6):2017-21. PMC: 2538874. DOI: 10.1073/pnas.0712053105. View

11.

Margolis K, Manson J, Greenland P, Rodabough R, Bray P, Safford M . Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study. Arch Intern Med. 2005; 165(5):500-8. DOI: 10.1001/archinte.165.5.500. View

12.

Arsenault B, Cote M, Cartier A, Lemieux I, Despres J, Ross R . Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure. Atherosclerosis. 2009; 207(2):530-3. PMC: 2818701. DOI: 10.1016/j.atherosclerosis.2009.05.009. View

13.

Horne B, Anderson J, John J, Weaver A, Bair T, Jensen K . Which white blood cell subtypes predict increased cardiovascular risk?. J Am Coll Cardiol. 2005; 45(10):1638-43. DOI: 10.1016/j.jacc.2005.02.054. View

14.

Johannsen N, Priest E, Dixit V, Earnest C, Blair S, Church T . Association of white blood cell subfraction concentration with fitness and fatness. Br J Sports Med. 2008; 44(8):588-93. DOI: 10.1136/bjsm.2008.050682. View

15.

Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28(7):412-9. DOI: 10.1007/BF00280883. View

16.

Grimm Jr R, Neaton J, Ludwig W . Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortality. JAMA. 1985; 254(14):1932-7. View

17.

Gillum R, Mussolino M, Madans J . Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol. 2005; 15(4):266-71. DOI: 10.1016/j.annepidem.2004.08.009. View

18.

de Gonzalo-Calvo D, Fernandez-Garcia B, de Luxan-Delgado B, Rodriguez-Gonzalez S, Garcia-Macia M, Suarez F . Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men. Age (Dordr). 2011; 34(3):761-71. PMC: 3337937. DOI: 10.1007/s11357-011-9266-9. View

19.

Church T, Finley C, Earnest C, Kampert J, Gibbons L, Blair S . Relative associations of fitness and fatness to fibrinogen, white blood cell count, uric acid and metabolic syndrome. Int J Obes Relat Metab Disord. 2002; 26(6):805-13. DOI: 10.1038/sj.ijo.0802001. View

20.

Kakanis M, Peake J, Brenu E, Simmonds M, Gray B, Hooper S . The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. Exerc Immunol Rev. 2010; 16:119-37. View