HBV-related Hepatocellular Carcinoma Susceptibility Gene KIF1B is Not Associated with Development of Chronic Hepatitis B

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Feb 25

PMID 22363396

Citations 13

Authors

Rong Zhong

Yao Tian

Li Liu

Qian Qiu

Ying Wang

Rui Rui

Bei-Fang Yang

Sheng-Yu Duan

Jun-Xin Shi

Xiao-Ping Miao

Li Wang

Hui Li

Affiliations

Soon will be listed here.

Abstract

Background: A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in KIF1B in the development of chronic hepatitis B.

Methodology/principal Findings: Three KIF1B polymorphisms (rs8019, rs17401924, and rs17401966) were selected and genotyped in 473 CHB patients and 580 controls with no history of CHB. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression model. None of these three SNPs showed association with CHBs after adjusting for age and gender. Equivalence-based method analysis confirmed the absence of association. In the further haplotype analysis, three common haplotypes were observed in this study population, but no significant effect was also found for haplotypes in the progression to CHB.

Conclusions/significance: This study showed the new locus identified for HCC, KIF1B, was not associated with progression to CHB, implying distinct genetic susceptibility factor contributes to the progression from hepatitis B virus infection to HCC. Nevertheless, further comprehensive analyses are warranted to dissect the mechanism.

Citing Articles

Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies.

Akcay I, Katrinli S, Ozdil K, Dinler Doganay G, Doganay L World J Gastroenterol. 2018; 24(30):3347-3360.

PMID: 30122875 PMC: 6092584. DOI: 10.3748/wjg.v24.i30.3347.

Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort.

Chen J, Wang Y, Lv W, Gan Y, Chang W, Tian N World J Gastroenterol. 2016; 22(16):4183-90.

PMID: 27122668 PMC: 4837435. DOI: 10.3748/wjg.v22.i16.4183.

Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension.

Yang W, Zhu Z, Wang J, Ye W, Ding Y Saudi Med J. 2015; 36(9):1039-45.

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Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.

Shi T, Jiang Z, Jiang R, Yin S, Wang M, Yu K Tumour Biol. 2015; 36(9):6919-27.

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Hepatitis B virus and host factors.

Yano Y, Seo Y, Azuma T, Hayashi Y Hepatobiliary Surg Nutr. 2014; 2(2):121-3.

PMID: 24570927 PMC: 3924661. DOI: 10.3978/j.issn.2304-3881.2012.10.10.

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