A Central Role for Long Non-coding RNA in Cancer

Overview

Journal Front Genet

Date 2012 Feb 25

PMID 22363342

Citations 87

Authors

Sheetal A Mitra

Anirban P Mitra

Timothy J Triche

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct class of ncRNAs in cancer-associated pathways that govern mechanisms such as cell growth, invasion, and metastasis. We also highlight the possibility of using these unique RNAs as diagnostic and prognostic biomarkers in malignancies.

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