The Human Side of Influenza

Overview

Journal J Leukoc Biol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2012 Feb 25

PMID 22362872

Citations 12

Authors

Christine M Oshansky

Paul G Thomas

Affiliations

Soon will be listed here.

Abstract

A clear understanding of immunity in individuals infected with influenza virus is critical for the design of effective vaccination and treatment strategies. Whereas myriad studies have teased apart innate and adaptive immune responses to influenza infection in murine models, much less is known about human immunity as a result of the ethical and technical constraints of human research. Still, these murine studies have provided important insights into the critical correlates of protection and pathogenicity in human infection and helped direct the human studies that have been conducted. Here, we examine and review the current literature on immunity in humans infected with influenza virus, noting evidence offered by select murine studies and suggesting directions in which future research is most warranted.

Citing Articles

Dynamic metabolic reprogramming in dendritic cells: An early response to influenza infection that is essential for effector function.

Rezinciuc S, Bezavada L, Bahadoran A, Duan S, Wang R, Lopez-Ferrer D PLoS Pathog. 2020; 16(10):e1008957.

PMID: 33104753 PMC: 7707590. DOI: 10.1371/journal.ppat.1008957.

ZBP1/DAI-Dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis.

Thomas P, Shubina M, Balachandran S Curr Top Microbiol Immunol. 2020; 442:41-63.

PMID: 31970498 DOI: 10.1007/82_2019_190.

Innovative Mucosal Vaccine Formulations Against Influenza A Virus Infections.

Calzas C, Chevalier C Front Immunol. 2019; 10:1605.

PMID: 31379823 PMC: 6650573. DOI: 10.3389/fimmu.2019.01605.

Burden, effectiveness and safety of influenza vaccines in elderly, paediatric and pregnant populations.

Sullivan S, Price O, Regan A Ther Adv Vaccines Immunother. 2019; 7:2515135519826481.

PMID: 30793097 PMC: 6376509. DOI: 10.1177/2515135519826481.

Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention.

Smallwood H, Duan S, Morfouace M, Rezinciuc S, Shulkin B, Shelat A Cell Rep. 2017; 19(8):1640-1653.

PMID: 28538182 PMC: 5599215. DOI: 10.1016/j.celrep.2017.04.039.

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