Alpha 2.0
Login Register
» Articles » PMID: 223612

Antibodies to Coxsackie B Viruses in Congestive Cardiomyopathy

Overview
Journal Br Heart J
Specialty Cardiology & Vascular Diseases
Date 1979 Jun 1
PMID 223612
Citations 40
Authors
G Cambridge
C G Macarthur
A P WATERSON
J F Goodwin
C M Oakley
Affiliations
Soon will be listed here.
Abstract

Fifty patients with congestive cardiomyopathy have been studied for evidence of previous Coxsackie B virus infection and compared with age- and sex-matched controls who had been admitted to hospital for investigation of other cardiac diseases. High neutralisation titres (greater than or equal to 1024) to Coxsackie B viruses were more common among the controls. On subdividing the patients according to their length of symptomatic history before study, high titres were more common only in those with a short history (less than or equal to 1 year). High titres were more common when there had been a febrile illness at the onset of symptoms. Endomyocardial biopsies of 18 patients disclosed no evidence of myocarditis, or, in 12 cases, of viral involvement. Although the evidence remains circumstantial, these results support the theory that Coxsackie B viruses may cause congestive cardiomyopathy and encourage further research into the mechanisms of myocardial cell damage by these visuses.

Citing Articles

Seasonal Testing, Results, and Effect of the Pandemic on Coxsackievirus Serum Studies.

Kordi R, Chang A, Hicar M Microorganisms. 2024; 12(2).

PMID: 38399771 PMC: 10893248. DOI: 10.3390/microorganisms12020367.

Advancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches.

Baumeier C, Harms D, Aleshcheva G, Gross U, Escher F, Schultheiss H J Clin Med. 2023; 12(15).

PMID: 37568452 PMC: 10419903. DOI: 10.3390/jcm12155050.

Clinical applications of multi-parametric CMR in myocarditis and systemic inflammatory diseases.

Lagan J, Schmitt M, Miller C Int J Cardiovasc Imaging. 2017; 34(1):35-54.

PMID: 28130644 PMC: 5797564. DOI: 10.1007/s10554-017-1063-9.

Coxsackievirus B detection in cases of myocarditis, myopericarditis, pericarditis and dilated cardiomyopathy in hospitalized patients.

Gaaloul I, Riabi S, Harrath R, Hunter T, Hamda K, Ghzala A Mol Med Rep. 2014; 10(6):2811-8.

PMID: 25241846 PMC: 4227425. DOI: 10.3892/mmr.2014.2578.

[Etiology, diagnosis, management, and treatment of myocarditis. Position paper from the ESC Working Group on Myocardial and Pericardial Diseases].

Pankuweit S, Maisch B Herz. 2013; 38(8):855-61.

PMID: 24165990 DOI: 10.1007/s00059-013-3988-7.

References
1.
Konno S, Sakakibara S . ENDO-MYOCARDIAL BIOPSY. Dis Chest. 1963; 44:345-50. DOI: 10.1378/chest.44.4.345. View
2.
Sanders V . IDIOPATHIC DISEASE OF MYOCARDIUM. A PROSPECTIVE STUDY. Arch Intern Med. 1963; 112:661-76. View
3.
Wong C, Woodruff J, Woodruff J . Generation of cytotoxic T lymphocytes during coxsackievirus tb-3 infection. II. Characterization of effector cells and demonstration cytotoxicity against viral-infected myofibers1. J Immunol. 1977; 118(4):1165-9. View
4.
Wong C, Woodruff J, Woodruff J . Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. I. Model and viral specificity1. J Immunol. 1977; 118(4):1159-64. View
5.
Dash H, Johnson R, Dinsmore R, HARTHORNE J . Cardiomyopathic syndrome due to coronary artery disease. I: Relation to angiographic extent of coronary disease and to remote myocardial infarction. Br Heart J. 1977; 39(7):733-9. PMC: 483310. DOI: 10.1136/hrt.39.7.733. View