Granulocytes in Helminth Infection -- Who is Calling the Shots?

Overview

Journal Curr Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2012 Feb 25

PMID 22360486

Citations 40

Authors

B L Makepeace

C Martin

J D Turner

S Specht

Affiliations

Soon will be listed here.

Abstract

Helminths are parasitic organisms that can be broadly described as "worms" due to their elongated body plan, but which otherwise differ in shape, development, migratory routes and the predilection site of the adults and larvae. They are divided into three major groups: trematodes (flukes), which are leaf-shaped, hermaphroditic (except for blood flukes) flatworms with oral and ventral suckers; cestodes (tapeworms), which are segmented, hermaphroditic flatworms that inhabit the intestinal lumen; and nematodes (roundworms), which are dioecious, cylindrical parasites that inhabit intestinal and peripheral tissue sites. Helminths exhibit a sublime co-evolution with the host's immune system that has enabled them to successfully colonize almost all multicellular species present in every geographical environment, including over two billion humans. In the face of this challenge, the host immune system has evolved to strike a delicate balance between attempts to neutralize the infectious assault versus limitation of damage to host tissues. Among the most important cell types during helminthic invasion are granulocytes: eosinophils, neutrophils and basophils. Depending on the specific context, these leukocytes may have pivotal roles in host protection, immunopathology, or facilitation of helminth establishment. This review provides an overview of the function of granulocytes in helminthic infections.

Citing Articles

Immunological and Haematological Relevance of Helminths and Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso.

Djibougou D, Mensah G, Kabore A, Toe I, Sawadogo L, Lompo P Biomedicines. 2024; 12(7).

PMID: 39062045 PMC: 11274831. DOI: 10.3390/biomedicines12071472.

Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients.

Debrah L, Gyasi C, Ahiadorme M, Rahamani A, Opoku V, Obeng P BMC Infect Dis. 2024; 24(1):384.

PMID: 38589790 PMC: 11003075. DOI: 10.1186/s12879-024-09278-0.

Enhanced protective immunity against Baylisascaris schroederi infection in mice through a multi-antigen cocktail vaccine approach.

Xiong L, Chen Y, Chen L, Hua R, Shen N, Yang G Parasitol Res. 2023; 123(1):20.

PMID: 38072876 DOI: 10.1007/s00436-023-08016-w.

Teleost innate immunity, an intricate game between immune cells and parasites of fish organs: who wins, who loses.

Sayyaf Dezfuli B, Lorenzoni M, Carosi A, Giari L, Bosi G Front Immunol. 2023; 14:1250835.

PMID: 37908358 PMC: 10613888. DOI: 10.3389/fimmu.2023.1250835.

Tegument Ultrastructure and Morphology of the Capsule Surrounding the Tetrathyridia of the Genus Mesocestoides Vaillant, 1863 in the Liver of the Root Vole.

Pospekhova N, Kusenko K Dokl Biol Sci. 2023; 511(1):213-221.

PMID: 37833575 DOI: 10.1134/S0012496623700461.

References

Ishida K, Yoshimura K . Characterization of monoclonal antibodies against eosinophil chemotactic factors from young adult worms of Angiostrongylus cantonensis. Parasite Immunol. 1992; 14(6):633-44. DOI: 10.1111/j.1365-3024.1992.tb00035.x. View

Tanaka J, Torisu M . Anisakis and eosinophil. I. Detection of a soluble factor selectively chemotactic for eosinophils in the extract from Anisakis larvae. J Immunol. 1978; 120(3):745-9. View

Hoerauf A, Schmetz C, Blaxter M, Buttner D, Gallin M, Al-Qaoud K . Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J Clin Invest. 1999; 103(1):11-8. PMC: 407866. DOI: 10.1172/JCI4768. View

Gruden-Movsesijan A, Petrovic M, Sofronic-Milosavljevic L . Interaction of mannan-binding lectin with Trichinella spiralis glycoproteins, a possible innate immune mechanism. Parasite Immunol. 2004; 25(11-12):545-52. DOI: 10.1111/j.0141-9838.2004.00665.x. View

Iwasaki K, Torisu M . Anisakis and eosinophil. II. Eosinophilic phlegmon experimentally induced in normal rabbits by parasite-derived eosinophil chemotactic factor (ECF-P). Clin Immunol Immunopathol. 1982; 23(3):593-605. DOI: 10.1016/0090-1229(82)90322-1. View

Mastin A, Bickle Q, Wilson R . Schistosoma mansoni: migration and attrition of irradiated and challenge schistosomula in the mouse. Parasitology. 1983; 87 (Pt 1):87-102. DOI: 10.1017/s0031182000052446. View

Cho M, Ahn S, Kim D, Yu H . Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation. Parasite Immunol. 2010; 32(5):354-60. DOI: 10.1111/j.1365-3024.2009.01195.x. View

Camp C, Leid R . Chemokinetic factors obtained from the larval stage of the cestode, Taenia taeniaeformis. Parasite Immunol. 1982; 4(5):373-81. DOI: 10.1111/j.1365-3024.1982.tb00449.x. View

Dombrowicz D, Quatannens B, Papin J, Capron A, Capron M . Expression of a functional Fc epsilon RI on rat eosinophils and macrophages. J Immunol. 2000; 165(3):1266-71. DOI: 10.4049/jimmunol.165.3.1266. View

10.

Sur S, Crotty T, Kephart G, Hyma B, Colby T, Reed C . Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?. Am Rev Respir Dis. 1993; 148(3):713-9. DOI: 10.1164/ajrccm/148.3.713. View

11.

Chaible L, Alba-Loureiro T, Maia A, Pugine S, Valle C, Pithon-Curi T . Effect of Cysticercus cellulosae on neutrophil function and death. Vet Parasitol. 2005; 127(2):121-9. DOI: 10.1016/j.vetpar.2004.09.023. View

12.

Al-Qaoud K, Pearlman E, Hartung T, Klukowski J, Fleischer B, Hoerauf A . A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5. Int Immunol. 2000; 12(6):899-908. DOI: 10.1093/intimm/12.6.899. View

13.

Mohrs K, Wakil A, Killeen N, Locksley R, Mohrs M . A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity. 2005; 23(4):419-29. PMC: 2826320. DOI: 10.1016/j.immuni.2005.09.006. View

14.

Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y . Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007; 110(3):913-20. DOI: 10.1182/blood-2007-01-068718. View

15.

Niwa A, Miyazato T . Reactive oxygen intermediates from eosinophils in mice infected with Hymenolepis nana. Parasite Immunol. 1996; 18(6):285-95. DOI: 10.1046/j.1365-3024.1996.d01-102.x. View

16.

Pearce E, Caspar P, Grzych J, Lewis F, Sher A . Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med. 1991; 173(1):159-66. PMC: 2118762. DOI: 10.1084/jem.173.1.159. View

17.

Heneberg P, Draberova L, Bambouskova M, Pompach P, Draber P . Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts. J Biol Chem. 2010; 285(17):12787-802. PMC: 2857068. DOI: 10.1074/jbc.M109.052555. View

18.

Nagase H, Okugawa S, Ota Y, Yamaguchi M, Tomizawa H, Matsushima K . Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand. J Immunol. 2003; 171(8):3977-82. DOI: 10.4049/jimmunol.171.8.3977. View

19.

Fabre V, Beiting D, Bliss S, Gebreselassie N, Gagliardo L, Lee N . Eosinophil deficiency compromises parasite survival in chronic nematode infection. J Immunol. 2009; 182(3):1577-83. PMC: 3923382. DOI: 10.4049/jimmunol.182.3.1577. View

20.

Chiaramonte M, Schopf L, Neben T, CHEEVER A, Donaldson D, Wynn T . IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J Immunol. 1999; 162(2):920-30. View