Factors Associated to Duration of Hepatitis a Outbreaks: Implications for Control

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Feb 23

PMID 22355358

Citations 2

Authors

Nuria Torner

Sonia Broner

Ana Martinez

Cecilia Tortajada

Patricia Garcia de Olalla

Irene Barrabeig

MariaRosa Sala

Neus Camps

Sofia Minguell

Josep Alvarez

Gloria Ferrus

Roser Torra

Pere Godoy

Angela Dominguez

Affiliations

Soon will be listed here.

Abstract

Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 10(5) persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94-0.98) and school setting (OR = 0.39; 95% CI: 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration.

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